Vion IMS QTof
Vion IMS QTof is a high resolution QTof mass spectrometer that delivers the selectivity of ion mobility to every scientist, for every analysis. Does high resolution, accurate mass data always lead to the correct answer first time? Avoid additional confirmatory experiments by utilizing the selectivity of ion mobility. Featuring new geometry and including XS Ion Optics and the QuanTof2 detection system, the Vion IMS QTof has…
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Great performance
Natural products and metabolites ID
We’re quite happy with the performance of the equipment and the way of visualising the results, identification and quantification-based. Easy of use. Software can be tricky some times but you can deal with it.
Review Date: 15 Jun 2023 | Waters
Good instrument for routine analysis but not for rocket science.
Protein characterization
The instrument is easy to setup and run the analysis with Waters Unifi software. All you need is on the same PC workstation: from data acquisition, processing up to reporting and archiving. Waters Unifi remove problematic data transfer. The cons however are to much limited options for user and even system administrator. For example if your system do not pass calibration one you can do is call the service. IMS is helpful but is not spectacular as described.
Review Date: 3 Feb 2023 | Waters
The Waters Vion IMS QTof: An Excellent Mass Spectrometer!
Protein characterization
The Vion IMS QTof is a very sophisticated mass spectrometer! With the Unifi software one is able to characterize proteins, perform peptide mapping and discover small molecules! Quite easy to use!
Review Date: 7 Feb 2022 | Waters
Great platform for biosimilars characterization!!
Biosimilars Characterization
Single software-UNIFI for data analysis data acquition and report generation. Software is 21FR compliant. Service and support from Waters is very good.
Review Date: 10 Feb 2020 | Waters
The analytical specificity & advanced data processing dramatically affects our work.
Arctic marine bioprospecting
Vion IMS QTof requires less set-up time, and because all the data is collected in one analysis, the need to reacquire is eliminated. Acquiring all data in one analysis combined with the added specificity from ion mobility provides Marbio researchers with the confidence to make better decisions, faster.
Review Date: 23 Apr 2019 | Waters
Super instrument if you can afford it
Food Analysis
High-quality and reliable results. Very powerful software make data processing very easy. Ion-mobility is a must if you sample contains a lot of isomers.
Review Date: 21 Nov 2018 | Waters
Vion IMS QTof is a high resolution QTof mass spectrometer that delivers the selectivity of ion mobility to every scientist, for every analysis.
Does high resolution, accurate mass data always lead to the correct answer first time? Avoid additional confirmatory experiments by utilizing the selectivity of ion mobility. Featuring new geometry and including XS Ion Optics and the QuanTof2 detection system, the Vion IMS QTof has the sensitivity and dynamic range to make ion mobility quantitative and routinely usable, enabling:
- Easier data interpretation as ion mobility cleans up and simplifies every spectrum
- Confident identification and quantification of analytes
- Faster method development and higher sample throughput
- Greater selectivity than conventional MS/MS with HDMSE
With Vion IMS QTof you can use the selectivity of ion mobility to quickly refine spectra and discount chromatographically co-eluting compounds and background interferences. Enabling you to characterize your compounds with confidence.
The ability to gather and process CCS data for every ion gives you more confidence in your data than ever before. Vion IMS QTof is driven by UNIFI scientific information system to deliver the most comprehensive analytical workflow, enabling you to target, identify, and review results in a single software platform. Make more informed decisions, faster.
CCS provides chromatographic retention time independent data points, enabling confident identification of your analytes and reducing the risk of false positives and false negatives. Even during initial sample analysis, without any retention time knowledge, you can use theoretical exact mass and CCS library values to identify unknown and unexpected components.
Applications:
- Screening - Meeting legislative and regulatory demands requires the utmost confidence in your data. UNIFI informatics workflows integrate the value of CCS, reducing false positives and false negatives driving laboratory efficiency.
- Pharma - The combination of UNIFI and Vion IMS QTof brings ion mobility to your drug discovery experiments while maintaing ease and efficiency you need for your routine Met ID processes.
- Omics - A recurring challenge for omics studies is the identification and structural elucidation of metabolites, lipids, and peptides of interest. Incorporating Vion IMS QTof into your workflow gives you not only CSS data from every component, but also increase analytical space and resolution.
Automated Monoclonal Antibody Modification with Waters UNIFI Scientific Information System
In this application note, Waters demonstrates how the UNIFI Scientific Information System can be used to tackle the challenge of data processing in monoclonal antibody (mAb) modification analysis, using the NIST mAb reference material as a relevant test case. When used in conjunction with the Vion IMS QTof mass spectrometer, the UNIFI system promises to control data acquisition, data processing and reporting, providing an end-to-end platform for probing a variety of mAb modifications with high confidence.
Ion Mobility-Enabled Data-Dependent Experiments Distinguishing Co-Eluting Isomeric Metabolites Using an IMS-QTof Mass Spectrometer
LC-MS/MS using data-dependent acquisition (DDA) is widely used for characterization of metabolites in drug metabolism studies. In this application note, nefazodone was incubated with rat hepatocytes and analyzed using both DDA and IMS-enabled DDA and co-eluting metabolites were characterized.
Building a Collision Cross-Section Library of Pharmaceutical Drugs Using the Vion IMS QTof Platform
Ion mobility separates ions according to their size and shape, and reports the separation as either the drift time or the collision cross-section (CCS). This application note explores the ion mobility utility of the Waters Vion MS and SYNAPT platforms for CSS analysis of pharmaceuticals.
Ion Mobility-Enabled Data-Dependant Experiments Distinguishing Co-Eluting Isomeric Metabolites
This application note explores the benefits of incorporating ion mobility separation measurements with data-dependent acquisition experiments.
Analysis of Synthetic Cannabinoids Using Ion Mobility Enabled High-Resolution Mass Spectrometry
In recent years, there has been a steady increase in the use of synthetic cannabinoids for recreational purposes. This application note presents a study assessing the feasibility of using collision cross section (CCS) data to facilitate differentiation of two isomeric synthetic cannabinoids.
Peptide Mapping with Higher Confidence: The Application Capability of IMS QTof Mass Spectrometry with Four-dimension (4D) Peak Detection (RT, m/z, intensity, and CCS values)
This application note describes a biotherapeutic analysis solution that offers both high quality data and a robust and compliant operating software: a high-performing AQUITY UPLC H-Class Bio and Vion IMS QTof System operated by UNIFI software. In this example the system is used for routine peptide mapping. The Vion IMS QTof, paired with UNIFI, delivers highly accurate and stable mass measurements, as well as robust and consistent CCS measurements for each peptide.
High-Performance Vion IMS QToF for Monoclonal Antibody Intact and Subunit Mass Analysis
High-resolution mass spectrometry is commonly used for assessment of the product quality and safety of biotherapeutic protein products. In this application note, Vion IMS QToF Mass Spectrophotometer was integrated with a compliant-ready informatics tool, UNIFI Scientific Information System, for intact mAb and subunit mass analysis. This system delivers accurate and reproducible mass measurements at the intact and subunit levels and enables confident identification and robust quantification of the protein modifications.
Waters Program for ASMS 2016
Join us at the 64th ASMS Conference on Mass Spectrometry and Allied Topics and find out more about Waters latest technologies and innovations that enable superior performance in your lab, allowing you to succeed in the science of what’s possible.
Starting on Saturday, June 4th, be sure to attend Waters MS Users’ Meeting at ASMS 2016 at the San Antonio Marriott Rivercenter, where you'll hear from renowned guest speakers, who are leading the way in the field of mass spectrometry and join other MS users at the afternoon parallel sessions covering key application areas.
Join us for breakfast June 6th, 7th and 8th at one of 7 informative technical seminars.
Get a sneak preview now of the many new mass spectrometry products and technologies we'll be showing you in our Waters Hospitality Suite in Texas Ballrooms B & C at the Grand Hyatt San Antonio.
Don't forget to review the various oral and poster presentations Waters experts will be giving and download the presentation schedule so you can add to your daily agenda.
See you at ASMS in San Antonio!
Characterization and Collision Cross Section Determination of Obesity Related Lipids Within Mouse Models Using Travelling Wave IMS-QTOF Mass Spectrometry
This poster demonstrates the characterization of the liver cell lipid complement using ion-mobility and associated collision cross section (CCS) databases, obtained with a novel geometry travelling wave IMS-QTOF MS platform, for obese mouse models which have undergone treatment to prevent or reverse obesity. Obesity is a risk factor associated with metabolic syndrome, and can be affected by manipulation of glucosylceramide levels, through treatment with glucosylceramide synthase inhibitors.
Enabling Fast Prototyping and Customisation of Mass Spectrometer Control Software
This poster describes the use of the web-based MS control program "WREnS" (Waters Research Enabled Software) with Waters' new IMS-QToF instrument, Vion. Here, it allows the user a faster and more flexible control and development architecture.
Analysis of Persistent Organic Pollutants Using Ion Mobility Mass Spectrometry
Learn how ion mobility mass spectrometry is used to analyze persistent organic pollutants. Watch this video to find out how the technique employs both mass and shape of the complexes being analyzed and how it’s used to discover new pollutants that are harmful.
Answering Big Questions in Structural Biology Using Ion Mobility Mass Spectrometry
Hear how ion mobility mass spectrometry is enabling big questions in structural biology to be understood. Collision cross section values allow the study of proteins and other molecules that have changed shape, but may not have changed mass, such as the proteins that cause bovine spongiform encephalopathy, commonly known as mad cow disease.
Analyzing Very Large Protein Complexes Using Ion Mobility Mass Spectrometry
Ion mobility mass spectrometry technology from Waters is being utilized by the Ohio State University. This diverse technique can be used on a variety of molecules and applications, including fragmentation of large protein complexes. Watch this video to see how the research group has successfully elucidated the structure of a previously unmapped protein.
Analysis of Co-Eluting Natural Sweeteners using Ion Mobility Mass Spectrometry
Learn how Severine Goscinny, of the Federal Scientific Institute for Public Health (Belgium), uses ion mobility-mass spectrometry from Waters to detect and quantify a new type of natural sweetener. Steviol glycosides are difficult to separate as their fragments often co-elute and have identical masses. However, the innovative Vion Q-TOF from Waters makes such fast and accurate separation easy.
The Vion IMS QTof Mass Spectrometer from Waters
Watch this video to see how the Vion IMS QTof Mass Spectrometer combines the benefits of high-resolution tandem mass spectrometry and ion mobility separation in a bench top instrument. Find, identify, and quantify all your analytes confidently.
Join Waters at the 54th Annual North American Chemical Residue Workshop (NACRW)
Waters is proud to be a Platinum sponsor of NACRW 2017
Latest Mass Spectrometry News and Interviews
A round up of the latest mass spectrometry related news, interviews and videos from around the world
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Discover the Latest in Metabolite Analysis
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Highlights from ASMS 2015
SelectScience attended this year's ASMS show to bring you the latest new and advances in mass spectrometry
Waters New Vion IMS Q-Tof Mass Spectrometer Brings the Benefits of Ion Mobility and Greater Separation Power to Routine Analyses
Now in a bench top tandem mass spectrometer, ion mobility adds new levels of clarity, confidence and productivity to the analytical laboratory
