Waters New Vion IMS Q-Tof Mass Spectrometer Brings the Benefits of Ion Mobility and Greater Separation Power to Routine Analyses
Now in a bench top tandem mass spectrometer, ion mobility adds new levels of clarity, confidence and productivity to the analytical laboratory
11 Jun 2015Waters Corporation (NYSE:WAT) today introduced the Vion™ IMS Q-Tof™ Mass Spectrometer at the 63rd conference of the American Society for Mass Spectrometry. Combining the benefits of high-resolution tandem mass spectrometry and ion mobility separation in a bench top instrument, the Waters® Vion IMS Q-Tof Mass Spectrometer brings clarity and confidence to routine analyses. Ion mobility removes spectral interferences and generates collision cross-section (CCS) values for every ion, giving scientists more information than they can get from traditional LC-MS experiments. Waters intends to commence shipments of the Vion IMS Q-Tof Mass Spectrometer in the second half of this year.
“More than a decade of experience in ion mobility has gone into the design of our Vion IMS Q-Tof instrument. For scientists involved in sample screening, metabolite identification, or classical ‘omics experiments, their ability to detect and identify all sample analytes in single analysis at the bench has reached a new level,” said Gary Harland, Director, Mass Spectrometry Product Management, Waters Division. “Regardless of how many analytes there are in a sample, and regardless of the concentrations which they are present in, Vion IMS QTof empowers laboratories to respond better to analytical challenges and succeed in meeting their scientific and business objectives.”
As routine analyses involve increasingly complex samples, scientists often rely on highresolution mass spectrometry. However, increasing mass resolution alone does not always lead to better answers. By separating ions from one another based on their shape, mass and charge, ion mobility provides an additional dimension of separation. The selectivity of ion mobility refines spectra and allows the instrument to discriminate sample ions from chromatographically co-eluting compounds and background interferences - bringing clarity to every spectrum, and enabling the confident characterization of compounds.
With Vion IMS Q-Tof, CCS measurements are carried out automatically, making them routinely available for every ion in an LC-MS experiment. Scientists now have a greater ability to confidently identify sample analytes and overcome typical day-to-day challenges, such as shifting retention times caused by matrix complexity and the use of different chromatography conditions.
The benefits of Vion IMS Q-Tof are underpinned by Waters travelling wave ion mobility, XS ion optics, and new QuanTof™ 2 technologies. QuanTof 2 delivers the dynamic range to make ion mobility routine, enabling its use in everyday quan/qual applications.
Vion IMS Q-Tof is driven by the industry-leading UNIFI® scientific information system, which provides a single platform for instrument control, data processing and reporting. The streamlined workflows increase productivity and enable faster and more informed decision-making.
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Vion IMS QTof
WatersVion IMS QTof is a high resolution QTof mass spectrometer that delivers the selectivity of ion mobility to every scientist, for every analysis. Does high resolution, accurate mass data always lead to the correct answer first time? Avoid additional confirmatory experiments by utilizing the selectivity of ion mobility. Featuring new geometry and including XS Ion Optics and the QuanTof2 detection system, the Vion IMS QTof has the sensitivity and dynamic range to make ion mobility quantitative and routinely usable, enabling: Easier data interpretation as ion mobility cleans up and simplifies every spectrum Confident identification and quantification of analytes Faster method development and higher sample throughput Greater selectivity than conventional MS/MS with HDMSE With Vion IMS QTof you can use the selectivity of ion mobility to quickly refine spectra and discount chromatographically co-eluting compounds and background interferences. Enabling you to characterize your compounds with confidence. The ability to gather and process CCS data for every ion gives you more confidence in your data than ever before. Vion IMS QTof is driven by UNIFI scientific information system to deliver the most comprehensive analytical workflow, enabling you to target, identify, and review results in a single software platform. Make more informed decisions, faster. CCS provides chromatographic retention time independent data points, enabling confident identification of your analytes and reducing the risk of false positives and false negatives. Even during initial sample analysis, without any retention time knowledge, you can use theoretical exact mass and CCS library values to identify unknown and unexpected components. Applications: Screening - Meeting legislative and regulatory demands requires the utmost confidence in your data. UNIFI informatics workflows integrate the value of CCS, reducing false positives and false negatives driving laboratory efficiency. Pharma - The combination of UNIFI and Vion IMS QTof brings ion mobility to your drug discovery experiments while maintaing ease and efficiency you need for your routine Met ID processes. Omics - A recurring challenge for omics studies is the identification and structural elucidation of metabolites, lipids, and peptides of interest. Incorporating Vion IMS QTof into your workflow gives you not only CSS data from every component, but also increase analytical space and resolution.