SelectScience Accelerating Science Feature
Next-generation sequencing and the advanced molecular toolkit
Modern life sciences labs have evolved from decoding single genes to mapping molecular networks across entire biological systems. Today, next-generation sequencing (NGS) technology and multiomics approaches (that combine genomics, proteomics, metabolomics, transcriptomics, and more) are unlocking unprecedented insights into life’s complexity. By leveraging advanced molecular biology toolkits and bioinformatics-driven big data analytics, scientists can explore intricate biological pathways, predict disease outcomes with precision, and design personalized therapies tailored to individual genomic profiles. This Accelerating Science Feature page highlights how the convergence of sequencing technologies and data science is transforming research and accelerating the future of precision medicine and human health.
Decoding life at scale with NGS
Join our upcoming Accelerating Science Forum for the unique opportunity to engage directly with our NGS experts and gain the practical guidance essential for optimizing your current workflows and for successfully solving complex sequencing challenges.
The online roundtable discussion – held in partnership with SPT Labtech – will bring together leaders in NGS to dive deep into the evolving landscape of genomics and the pivotal technologies delivering reliable sequencing outcomes.
Register nowReserve your free space to gain insights from leadings experts at University of Cambridge, Human Genome Sequencing Center at Baylor College of Medicine, and Earlham Institute.
This event is perfect for molecular biologists, lab managers, technicians, bioinformaticians, and researchers currently utilizing or planning to implement NGS technologies.
Custom Next-Gen Sequencing Oligos with high purity and low cross contamination
Regardless of platform, high-quality universal and index adapters enable proper fragment assembly. Adapters with excessive truncation or cross-contamination can cause adapter dimerization, compromised read integrity, and incorrect sequence assembly during multiplexing. To safeguard against failed runs, Merck’s custom Next-Gen Sequencing Oligos (NGSO) are manufactured under proprietary methods to ensure reliable performance for research, commercial, and molecular diagnostic applications.
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Expert guide to NGS technologies
Due to remarkable advances in genetic sequencing technology, researchers now have an abundance of tools at their disposal. Your choice of technique and technology must first and foremost complement your chosen application and help answer your specific research questions. From library prep to data analysis and interpretation, learn about the key NGS technologies, considerations for sample preparation, key application areas, and the future for NGS.
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Advanced sequencing transforms rare disease diagnostics for labs and patients
New research suggests that a single, comprehensive genetic test could dramatically reduce time to diagnosis, offering clarity for families and greater efficiency for labs.
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How to bring automated NGS to every oncology clinic
A fully automated NGS workflow empowers even small and community hospitals to deliver rapid, high-quality genomic insights in-house.
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The 6-base genome revolution for neuroscience and cancer research
Simultaneously analyzing both genetic sequences and epigenetic modifications (5mC and 5hmC) from a single sample provides a holistic view of cellular functions.
Read articleThe power of multiomics
Multiomics is an integrative approach that combines data from multiple omics layers, such as genomics, transcriptomics, proteomics, metabolomics, and epigenomics, to deliver a comprehensive view of biological systems. Rather than analyzing a single molecular level in isolation, multiomics captures the complex multi-layered interactions between genes, proteins, metabolites, and regulatory mechanisms, enabling researchers to understand how these components work together to influence health and disease.
This emerging field is revolutionizing systems biology and clinical research, providing insights that single-omics approaches cannot match. As high-throughput sequencing technologies, bioinformatics, and AI-driven computational analysis advance, multiomics is becoming a cornerstone for decoding biological complexity and driving personalized healthcare solutions.
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