PrimeMax™ CPG
A CPG solid support designed to maximise productivity and synthesis efficiency for oligonucleotide manufacturing.
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Key features
- Optimised pore architecture and loading range, delivering higher net full-length product (FLP) yield
- Contains silanol (TMS) end-capping chemistry, reducing side reactions and improving synthesis consistency
- Utilises our next-generation Native CPG manufacturing process, improving material efficiency and reducing waste production
Controlled pore glass (CPG) is a well-established solid support for solid-phase oligonucleotide synthesis, but conventional CPGs are often designed with pore sizes and loadings that are not optimised for modern manufacturing. As oligonucleotide length and synthesis scales evolve, sub-optimal pore architecture and surface loading can limit productivity, reduce efficiency, and introduce variability.
PrimeMax™ CPG is a next-generation controlled pore glass engineered to deliver predictable, high-productivity performance for oligo synthesis. It combines optimised pore size, controlled surface area normalised loading (SANL), and next-generation surface chemistry to maximise usable synthesis scale while maintaining product quality.
Our first iteration, PrimeMax™ siRNA CPG is designed with reduced pore diameters (typically ~360-440 Å) relative to conventional CPGs, increasing accessible surface area and enabling higher effective loading without the negative effects of overloading. Loading is specified based on surface area rather than mass, ensuring consistent utilisation of reactive sites and avoiding efficiency losses associated with excessive surface density.
The solid support is manufactured using LGC Biosearch Technologies’ next-generation Native CPG process and incorporates trimethylsilyl (TMS) end-capped LCAA chemistry to enhance stability and minimise side reactions during synthesis. Comparative synthesis studies demonstrate that PrimeMax™ siRNA CPG delivers significant improvements in net full-length product yield and overall productivity versus incumbent CPGs, while maintaining comparable crude and purified impurity profiles.
PrimeMax™ CPG is suitable for scalable siRNA manufacturing workflows where increased output, reproducibility, and efficient use of synthesis assets are critical.
Optimization of controlled pore glass for siRNA synthesis and the development of PrimeMax siRNA CPG
This whitepaper examines the optimization of controlled pore glass (CPG) solid supports for siRNA synthesis and introduces PrimeMax™ siRNA CPG, a next-generation support engineered to improve oligonucleotide manufacturing performance. Learn how surface area normalized loading (SANL), pore architecture, and TMS end-capped chemistry influence coupling efficiency, impurity formation, and full-length product yield. Discover comparative data demonstrating significant improvements in crude and purified siRNA yields, enhanced synthesis scale, and greater manufacturing efficiency, while maintaining product quality and supporting more sustainable oligonucleotide production workflows.
Resource details:
Resource type: Whitepaper
Page count: 12
Read time: 15 mins
The landscape of nucleic acid therapeutics
The rapid expansion of nucleic acid therapeutics, from early antisense oligos to today’s mRNA vaccines and CRISPR‑based gene therapies, has increased the complexity of oligonucleotide design. As modalities and targets diversify, researchers must better understand structures, modifications and how these influence performance.
Explore this resource to understand key therapeutic classes, from approved drugs like nusinersen to emerging formats such as self-amplifying RNA (saRNA). Gain clarity on structural components, critical nucleotide modifications, and the technologies shaping the next generation of oligo and mRNA medicines.
Rethinking solid support chemistry for scalable siRNA manufacturing
Dr. Catherine McKeen of LGC Diagnostics & Genomics - Biosearch Technologies Oligo Synthesis explains how solid support chemistry influences oligonucleotide yield and purity, and how customer collaboration shaped the development of PrimeMax™ CPG
