Optimization of controlled pore glass for siRNA synthesis and the development of PrimeMax siRNA CPG

This whitepaper examines the optimization of controlled pore glass (CPG) solid supports for siRNA synthesis and introduces PrimeMax™ siRNA CPG, a next-generation support engineered to improve oligonucleotide manufacturing performance. Learn how surface area normalized loading (SANL), pore architecture, and TMS end-capped chemistry influence coupling efficiency, impurity formation, and full-length product yield. Discover comparative data demonstrating significant improvements in crude and purified siRNA yields, enhanced synthesis scale, and greater manufacturing efficiency, while maintaining product quality and supporting more sustainable oligonucleotide production workflows.

Resource details:

Resource type: Whitepaper
Page count: 12
Read time: 15 mins