ImageXpress HCS.ai High-Content Screening System
A fast, intuitive and versatile system delivering deeper insights for every lab
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The ImageXpress® HCS.ai High-Content Screening System captures your imagination with high-quality imaging and analysis, enabling you to acquire the crystal-clear images and robust data you need with ease.
Powered by intuitive MetaXpress® Acquire software, the ImageXpress HCS.ai system integrates seamlessly with AI-driven IN Carta® Image Analysis Software for deep insights. An advanced, modular design offers the flexibility to perform a vast range of 2D and 3D assays in a single solution, while allowing for easy upgrades to meet evolving laboratory needs.
- Modular and intuitive for optional versatility: The ImageXpress HCS.ai system features a modular design and a wide array of customizable configuration options to meet your current needs and on-site upgrades to match your future requirements. The newly upgraded MetaXpress® Acquire software is an intuitive solution for users of all experience levels, providing direct access to reliable and insightful data.
- Higher quality images and superior data analysis for deeper insights: Acquire high-quality images across a vast range of assay types, obtain exceptional image quality from your 3D samples, and unlock new discoveries with AI-powered IN Carta® Image Analysis Software.
- Faster acquisition for accelerated high-throughput workflows: Boost lab productivity by imaging more plates in less time and simplifying the learning curve for new users. A new, automation friendly design enables you to integrate easily into automated workflows for faster, more reliable results.
Brochures
IN CARTA Image Analysis Software
IN Carta® Image Analysis Software is an AI-powered solution for fast, accurate analysis of complex biological images. Designed for 2D, 3D, and 4D experiments, it combines intuitive workflows, deep learning–based segmentation, and advanced data analytics to transform high-content imaging data into reliable, actionable insights so researchers can focus on discovery, not data processing.
Upgrade your existing imaging system with up to 20% off the ImageXpress HCS.ai
Take advantage of Molecular Devices’ limited-time promotion and upgrade your existing imaging system to the ImageXpress® HCS.ai High-Content Screening System. With up to 20% off, faster imaging speeds, AI-powered analysis, and flexible configuration options, now is the time to elevate your lab’s screening capabilities.
ImageXpress HCS.ai high-content screening system
In this product brochure, Molecular Devices® introduces the ImageXpress HCS.ai High-Content Screening System that captures your imagination with high-quality imaging and analysis, enabling you to acquire the data you need with ease.
Cellular imaging insights
The goal of many researchers is to elucidate the complex cellular pathways within 2D and 3D cellular structures in response to chemical stimulation or stress. The capacity to which scientists have access to and can adopt emerging cellular imaging and analysis technology fuels their level of understanding. In this eBook, Molecular Devices provides an overview of the new tools that can be used to better understand complex imaging models.
AI-enabled automated compound screening for toxicity effects using healthy human intestinal organoids
Discover how the CellXpress.ai® Automated Cell Culture System and the ImageXpress® HCS.ai High-Content Screening System deliver a fully automated, AI-powered workflow for compound toxicity screening using healthy human intestinal organoids.
This application note highlights a scalable solution that integrates automated organoid culture, compound dosing, and high-content imaging with machine learning–driven phenotypic analysis. By combining deep learning segmentation (SINAP) and phenotypic classification (Phenoglyphs™) found in IN Carta® Image Analysis Software, the system accurately distinguishes between cytotoxic, cytostatic, and viable organoid responses.
Scalable 3D organoid modeling for drug discovery
Discover how to overcome the challenges of scaling 3D organoid models for high-throughput drug discovery. This comprehensive guide delivered in partnership with Molecular Devices explores innovative solutions for automating organoid culture, screening, and analysis.
Download this SelectScience guide to explore:
- Patient-derived 3D Ready™ Organoids and Expansion Services
- The CellXpress.ai® Automated Cell Culture System
- High-content imaging with ImageXpress® HCS.ai and IN Carta® software
- AI-powered workflows for toxicity screening and phenotypic profiling
Ideal for researchers seeking reproducible, scalable, and human-relevant models to accelerate drug development and personalized medicine.
Resource details:
- Document type: SelectScience guide
- Page count: 36
- Read time: 54 mins
- Edition: 1st
The essential guide to organoids in drug discovery
In this application note, Molecular Devices provides a helpful guide on organoids in drug discovery. Three-dimensional (3D) organoid development is one of the most important advancements in drug discovery research to date. The ability to self-organize and mimic functional organ cell types is believed to better represent in vivo biology than 2D monolayer cell cultures. As such, organoids are becoming increasingly important in the fields of cancer research, neurobiology, stem cell research, and drug discovery. They provide important insights into the mechanisms of tissue development and disease, and present a very valuable approach for biological research and drug development.
Fueled by rapid developments in advanced cell technologies and the desire to create models that closely resemble the in vivo tissue, organoids have undeniably taken their rightful place at the forefront of disease modeling and drug discovery. Developed to represent many different organs of the human body, with applications expected to grow over the next few years, organoids form the foundation of innovations yet to come in precision, translational, and regenerative medicine.
AI-enabled automated compound screening for toxicity effects using healthy intestinal 3D organoids
This application note demonstrates the automation of a compound testing assay for toxicity assessment using human and mouse 3D intestinal organoids. Intestinal organoids were cultured, passaged, and expanded in Matrigel domes in 24 wells using the CellXpress.ai™ Automated Cell Culture System. The ImageXpress® HSC.ai High Content Screening System was used for the evaluation of toxicity effects by imaging and analysis of phenotypic changes in 3D organoids.
Using a next-generation high-content screening platform and AI-analysis tools to increase insights from the complex 3D assay
This application note demonstrates how Molecular Devices’ ImageXpress® HCS.ai system, combined with AI-powered IN Carta® analysis, delivers high-quality 3D imaging and phenotypic insights. Using patient-derived colorectal cancer organoids, the workflow enables precise segmentation, robust classification, and quantification of drug effects in complex biological assays.
High-speed phenotypic profiling using a next generation high-content imaging platform with AI-enabled image analysis
Learn how the new ImageXpress® HCS.ai High-Content Screening System from Molecular Devices® can improve acquisition speeds by an average of 40%, enabling faster screening compared to similar imagers. Three example assays are presented to illustrate how the new imager with its modern software interface follows a logical workflow from set-up to analysis. Find out how state-of-the-art image acquisition software and AI-enabled image analysis enable highly multiplexed assays and high-throughput screening of 2D and 3D assays.
Transforming high-content screening with intelligent imaging and AI analysis
June 26, 2025 at 16:00 BST / 17:00 CEST / 11:00 EDT / 08:00 PDT
High-content imaging is essential in drug discovery, but as assays grow more complex, researchers need faster, more powerful imaging and analysis tools to extract high-quality data efficiently.
Register for this exclusive webinar to hear from two Molecular Devices experts, Dr. Angeline Lim and Dr. Andy Bashford, as they share real-world applications, including phenotypic profiling and patient-derived organoid imaging, using a next-generation high-content screening system - ImageXpress® HCS.ai.
Discover how this platform can elevate your screening and image capturing with its enhanced imaging quality and AI-powered analysis, to improve assay reproducibility, produce deeper insights and take your screening to the next level.
Key learning objectives
- Master essential high-content imaging assays from 2D phenotypic profiling to 3D imaging using patient-derived organoids
- Discover the latest innovations in the ImageXpress HCS.ai platform and how it enhances speed, quality, and flexibility
- Explore the power of AI-driven analysis with IN Carta software to tackle the most challenging screening assays
Who should attend?
- Scientists, directors, managers and imaging specialists working in biotech, pharma and academic sectors.
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
Discover the ImageXpress HCS.ai High-Content Screening System
Today’s imaging labs must do more in less time, capturing high-quality data across a growing range of assays. Having the right tools to extract meaningful results, while remaining flexible enough to adopt new capabilities, is essential.
The ImageXpress HCS.ai High-Content Screening System delivers high-definition imaging and robust, reliable data with ease. Designed for both 2D and 3D cell assays, it empowers researchers to capture deeper insights faster and with confidence.
Key partnership increases access to organoid models
Patient-derived organoids address the urgent need for more predictive in vitro models for biopharmaceutical applications. However, challenges around standardization and scale up remain. Dr. Francisco Morales-Rodriguez shares insight into the partnership between HUB Organoids and Molecular Devices, which aims to increase the access of organoids for both academia and industry. Here, he highlights the integral role of the ImageXpress® Micro Confocal High-Content Imaging System and its suite of software solutions in providing high image quality, high throughput, and flexibility that HUB Organoids requires.
This video was filmed at SLAS Europe 2024.
