SelectScience Accelerating Science Feature
Organoids, spheroids, and complex living systems
In just a few decades, scientists have progressed from studying cells in flat layers to growing 3D cell culture models such as organoids and spheroids that accurately replicate human organ structure and function. These tiny but mighty organoid models provide a powerful platform for disease modeling, drug screening, and personalized medicine, offering insights into how our bodies develop, how cancer spreads, and how viruses attack, all without the limitations of traditional cell cultures or the ethical concerns of animal testing. As technologies advance through innovative 3D culture techniques, bioreactor systems, automation, high-resolution imaging, and AI-driven data analysis, organoid models are becoming more precise, scalable, and transformative for biomedical research. This Accelerating Science Feature page explores how these miniature, 3D versions of human organs are transforming the modern life sciences lab.
Mini organs, big breakthroughs
Our Accelerating Science Forum – held in partnership with Tecan – will bring together world-leading organoid experts to discuss:
- Actionable insights on how to move organoid models into high-throughput screening
- The critical path to achieving true functional maturity in multi-organ systems
- Predictions on the industry landscape, key applications, and pace of clinical adoption for organoids over the next five years
Join the online roundtable discussion to expand your understanding beyond the scientific complexity, and hear how to successfully transition organoids, spheroids, and powerful 3D models from the lab bench into high-throughput screening environments to truly deliver the next generation of life sciences and drug discovery research.
Register nowReserve your free space to gain insights from professors at Johns Hopkins University, Vanderbilt University, and Albert Einstein College of Medicine.
Validated stains for spheroids, organoids, and other 3D cultures
As adoption of 3D culture systems accelerates across a wide range of research fields, so does the demand for high-performance, validated cellular stains that can deliver clear, reliable results. This resource helpfully spotlights six key publications that showcase how Biotium’s unique cellular stains are successfully applied in labeling cells within spheroids, organoids, and other 3D culture systems, providing you with actionable insights and proven approaches to enhance your own 3D culture studies.
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How to enhance physiological relevance in 3D cell culture
To address limitations in organoid application, microphysiological systems (MPS) have emerged, which enable perfused cultures and improve tissue viability and function. Organ-on-a-chip (OOC) platforms go a step further by integrating multiple cell types and organ models for superior longevity, assay sensitivity, and biomarker generation. This whitepaper shares how these advanced in vitro models bridge preclinical and clinical gaps, reduce animal testing, and accelerate regulatory-compliant drug development.
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Organoid technologies offer new dimension to aging research
While aging is an apparent phenotype in humans, its underlying cause is still unknown and researchers at Albert Einstein College of Medicine aim to understand such mechanisms through a 3D lens.
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Significance of organoid maturity and functionality and how to get it
In this on-demand webinar, Dr. Qiang shares how advanced 3D culture techniques are accelerating organoid maturation, supporting neurovascular integration, and enhancing glial function.
Watch webinar
A comprehensive automated 3D cell culture workflow from Tecan
Automated hydrogel handling, cell seeding, spheroid cultivation, and drug response profiling can be achieved using the Fluent® Automation Workstation, D300e Digital Dispenser and Spark® Cyto multimode reader from Tecan.
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Expert guide to 3D biology solutions
From organoids and spheroids to organ-on-a-chip platforms and bioprinted tissues, modern 3D cell culture methods are revolutionizing disease model development and precision medicine research. Whether you are focused on cancer biology, drug screening, or working with patient-derived cells, choosing the right tools is critical. This free eBook provides expert guidance on selecting the best 3D biology solutions for your lab, with tips tailored to every stage of your workflow.
Download free eBookNew approach methodologies
New approach methodologies (NAMs) are innovative, non-animal testing strategies that use advanced technologies such as in vitro systems, computational modeling, and high-throughput screening to study biological processes and assess chemical safety. These methods are designed to provide more human-relevant data, reduce reliance on traditional animal models, and accelerate research by offering faster, cost-effective, and ethically responsible alternatives.
NAMs are crucial for the future of life sciences because they enable precision in predicting human responses, support regulatory compliance with evolving ethical standards, and foster breakthroughs in areas like toxicology, drug development, and environmental health. By integrating NAMs, researchers can improve scientific accuracy while promoting sustainability and humane practices in research.
Want to get the latest NAM news straight to your inbox? Become a member for free here.
