Fluent® Laboratory Automation Workstation

In this whitepaper, Tecan outlines the role of LC-MS in medical research and clinical diagnostics. Discover how you can implement a workflow aligned with your lab’s setup, with applications including the detection of vitamins, immunosuppressants, and psychotropic drugs. Real-world case studies show practical steps for adopting LC-MS into routine use. You will also find answers to common workflow and reagent handling questions.

The paper also introduces concentrated LC-MS kits, offering the equivalent analytical performance as standard kits, while reducing shipping weight, solvent volumes, and storage space. Learn how modular formats support focused procurement and lower overall lab costs.

This poster details a study to evaluate whole blood sample preparation and analysis of four commonly used immunosuppressants: Tacrolimus, Everolimus, Sirolimus and Cyclosporine A, by automation using the Tecan Fluent® 780 liquid hander and LC-MS kit compared to manual sample preparation methods. Sample tracking, processing efficiency, and resource consumption are compared to determine the suitability of the automated workflow for routine laboratory applications in immunosuppressant investigation.

This application note details an automated workflow for 3D cell culture. It includes controlled pipetting of Matrigel® matrix, cell seeding and spheroid cultivation using a Fluent Automation Workstation with an integrated, liquid-cooled four-position carrier and a Thermo Scientific™ Cytomat™ 2 C450-LiN automated incubator. Drug treatments were performed using the D300e Digital Dispenser. A Spark® Cyto multimode reader was used to monitor cell growth by brightfield imaging, as well as to perform luminescence-based viability assessment using the CellTiter-Glo® 3D Cell Viability Assay (Promega).

Sample extraction and purification are at the core of modern laboratory workflows, supporting vital fields like proteomics, genomics, and biopharmaceutical production. Automation is revolutionizing these processes by reducing human error, increasing throughput, and boosting lab efficiency.

The latest sample prep instruments integrate sample cleanup, evaporation, and resuspension into a single platform, making complex sample prep more efficient and scalable for everything from method development to large-scale purifications.

This eBook provides valuable resources and case studies to guide you through the latest automation technologies. Learn how Tecan’s cutting-edge lab instruments and automated workflow platforms can transform your lab’s efficiency and output.

Explore case studies such as:

• Semi-automated supercoiled plasmid DNA extraction
• Enhanced biomolecule cleanup in mass spectrometry
• Automated high-throughput plasma proteome sample preparation
• Simplified, automated sample preparation
• Automated on-column protein digestion and peptide desalting for high-throughput proteomics

Plasma proteomics is vital for identifying health and disease biomarkers, but the complexity of plasma samples poses challenges. Tecan describes a scalable and rapid automation platform for preparing plasma samples for proteomic analysis using the ENRICH-iST HT reagent kit, the Fluent® liquid handler, and the Resolvex® A200. The automated ENRICH-iST workflow addresses challenges by enriching low-abundance proteins, facilitating deeper protein identification and quantification compared to manual methods. Tecan highlights the efficiency and robustness of the automated process, showing high-throughput capabilities with minimal user intervention. It demonstrates consistent and reproducible results with over 97% overlap in protein identifications between manual and automated methods, making it a powerful tool for extensive plasma proteome studies.

Faced with a growing demand to maximize sample throughput and ensure result accuracy, many laboratories are now adopting automated liquid handling as part of their workflows.

Manual pipettes require scientists to dedicate a large part of their day to liquid handling. With automation, scientists are free to do other more meaningful activities in the lab. Liquid handling workstations are designed for complete workflow automation, enabling laboratories to automate various processes for even greater time savings.

In this infographic, we explore the key factors to consider when purchasing a liquid handling workstation including application considerations, return on investment, and software capabilities. Plus, discover top tips for laboratories looking to invest in automation for the first time.

In this application note, Tecan demonstrates the use of the PacBio SMRTbell® prep kit 3.0 and DreamPrep NGS Compact platform to automate the generation of DNA sequencing libraries. It shows that running automated workflows with minimal user interaction delivers high-quality and consistent libraries, allowing staff to undertake more meaningful work instead of performing long repetitive protocols.

In this application note, Tecan have collated some inspirational stories regarding the successes of scientists who have relied on Tecan products. These include: innovation in new paths for novel biologics, next-generation sequencing for the establishment of microbiota present in healthy individuals, faster processing for biosimilars, and, new approaches to in vitro sensitization testing. Have a read and see what you could accomplish.

You’ve done your testing on the benchtop and proven that your new biotechnology innovation works in your hands. Now comes the exciting part – turning your solution into a breakthrough product that is ready for broader use and commercial launch. To get there, you need to optimize your processes so that you can ensure they are robust, operate within defined tolerances, and facilitate scale-up. What’s the fastest and most efficient way to get this done so that you can focus on your next bioscience advancements?

In this casebook, Tecan presents a collection of studies from customers working in genomics, bioprocessing, and cell biology.

Friday, March 6 at 15:00 GMT | 16:00 CET | 10:00 EST | 07:00 PST

Organoids offer unprecedented insights, yet many laboratories are held back by the complexity and high cost of the required infrastructure. Typical workflows often demand sophisticated protocols and a high level of expertise that is simply not available in every lab.

In this 20-minute SelectScience TechTalk, we will introduce the Spark® Cyto, an imaging microplate reader designed to break down these barriers. Discover how this compact instrument, with integrated real-time environmental control, easily automates the monitoring and analysis of 3D structures such as organoids, enabling high-quality fluorescence and label-free imaging without a steep learning curve.

We will also demonstrate effortless assay multiplexing by integrating high-quality imaging data with quantitative metabolic readouts, such as ATP-based luminescence.

Key learning objectives:

• Understand how to perform live-cell imaging of 3D cultures, including organoids, with real-time environmental control
• Learn how to combine high-quality imaging with quantitative metabolic assays (e.g. ATP-based luminescence) for seamless multiplexed analysis
• Discover how AI-assisted image analysis simplifies data interpretation and reduces manual workload
• Explore strategies for automating 3D cell culture workflows to improve reproducibility, efficiency, and scalability

Who should attend?

• Researchers working with 3D cell cultures
• Anybody interested in automating cell-based assays

Certificate of attendance
If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.

Spark is for research use only. Not for use in diagnostic procedures.

TechTalk details

• Cost: Free to attend
• Location: Online
• Duration: 20 minutes

Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available

Hear how the Tecan Fluent® automated liquid handling platform can streamline preanalytical sample preparation for molecular, LC-MS, and immunoassay applications. Emanuele Oggioni, Sales Manager at Tecan, describes how Fluent® supports barcode tracking and how the platform can help you to reduce errors.

This video was filmed at Euromedlab 2025.

Tecan Labwerx produces beyond-the-ordinary solutions for automated laboratory workflows for the fast paced changes in the life sciences.

New automations in liquid biopsy research hold great promise for bringing us even closer to fully realizing its clinical utility in monitoring cancer from diagnosis through to remission

Hear how the Ocular Tissue Engineering Laboratory is addressing retinal cell culture challenges via an automated stem cell robot platform

Find out how research at HUB Organoids is paving the way for more effective cancer therapeutics

How a biopharmaceutical company successfully brought its compound management in-house with the help of automation

This collaboration will allow Tecan to expand its presence for these product lines and reach a wider customer base across the academic and biotech communities

The high-throughput system enables laboratories to double or even triple their testing capacity

NGS DreamPrep™ promises unprecedented speed and accuracy for automated library preparation