Separations Products & Reviews

For your volume critical filtering needs, we now offer the OPTI-SOLV® Micro Filter. Based on the same design that has made the Mini Filter a huge success, the Micro Filter cuts the internal volume to less than 200 nL but retains the ease of use and functionality of the Mini Filter. The Micro Filter is designed to be used in today's low volume, high sensitivity chromatographic applications as a last line of defense against debr…

The user-friendly Hand-Tight OPTI-SOLV® In-Line Filter System is well suited for a number of applications, such as high temperature, high-pressure environments where quick changes are imperative. The unique swivel design allows frits to be changed without removing the connecting tubing. Just plumb it once and leave it. The frictional forces generated at the piston/seal interface inevitably lead to particulate shedding. Placeme…

The user-friendly Wrench-Tight OPTI-SOLV® In-Line Filter System is well suited for a number of applications, such as high temperature, high-pressure environments where quick changes are imperative. The unique swivel design allows frits to be changed without removing the connecting tubing. Just plumb it once and leave it. The frictional forces generated at the piston/seal interface inevitably lead to particulate shedding. Place…

OPTI-GUARD® 1mm Biocompatible Guard Columns set the standard for extremely low impact, easy to use pre-column protection. Designed for use with analytical (4.6, 3.0 mm i.d.) and narrow-bore (2.1, 1.0 mm i.d.) columns, the patented floating stem design automatically adjusts to any manufacturer's tube stop depth for a zero-dead-volume connection every time. The best part? It's no larger than a standard fitting. Connecting the OP…

The OPTI-GUARD® 3 mm Columns maintains the tool-free connectivity of the OPTI-GUARD 1 mm, but incorporates a cartridge based format to allow for a larger bed with more capacity. The two-part holder is designed for use with any analytical column to provide vital protection from dirty samples and strongly retained contaminants. An auto-adjusting stem conforms to any tube stop depth for a perfect zero-dead-volume connections.Key…

OPTI-SEAL® Piston/Plunger Seals are the longest lasting seals on the market. Machined from either of two proprietary polymer blends, UHMW-PE or ITB, Optimize Seals provide the ultimate in high pressure sealing capacity. For mostly aqueous buffered mobile phases, OPTI-SEAL® UHMW-polyethylene is the wisest choice. Specially designed to be more resistant to abrasion and wear than standard polyethylene seals, they can last up to s…

Optimize realizes that your time is valuable and should not be wasted worrying about fittings. For this reason, all Opti-Lock Fittings are precision machined in the USA for optimal quality and thread consistency. The machining process is the best way to ensure tight manufacturing tolerances and minimal product variance. What does all this mean? It means that every fitting you purchase from Optimize will perform just as well as…

Optimize Back Pressure Regulators utilize an active mechanism to maintain steady back pressure across a range of mobile phase viscosities and flow rates. Placing one downstream from your detector will prevent solvent decompression and bubble formation in the flow cell, reducing baseline noise and drift. Each pre-set Optimize stainless steel Back Pressure Regulator offers a 100µL internal volume and includes fittings for immedi…

Optimize Replacement Pistons/Plungers are, by design, a consumable part of the HPLC pump and should be replaced on a regular preventative maintenance schedule. To maintain peak performance and avoid unplanned downtime, sapphire pistons require inspection every six months with yearly or as-needed replacement. Optimize sapphire pistons offer optimal concentricity and resistance to wear. Each sapphire rod is specifically cut in r…

The OPTI-LYNX™ Quick Connect Filters allow you to connect any 10-32 valve/port for trapping or analytical column for pre-column filtration. With OPTI-LYNX™, accessing and changing the insert takes only a quarter turn. Replace traps, filters or change configurations in seconds, without tools. OPTI-LYNX™ traps and filters (ordered separately) come in several bed volume/ diameter/ porosity combinations, allowing you to find your…

The OPTI-LYNX™ Quick Connect Trap Columns allow you to quick-connect to any 10-32 valve/port for trapping or analytical column for pre-column filtration. With OPTI-LYNX™, accessing and changing the insert takes only a quarter turn. Replace traps, filters or change configurations in seconds, without tools. OPTI-LYNX™ traps and filters (ordered separately) come in several bed volume/ diameter/ porosity combinations, allowing you…

The OPTI-LYNX™ QuickConnect Guard Column is a high-performance, cartridge-based guard system, suitable for use with any 10-32 analytical column due to its auto-adjusting ZDV port adapter. OPTI-LYNX™ combines effective column protection with the convenience of quick-connect operation. Some cartridge-based guard column products offer convenience with a price: higher internal volumes. Optimize Technologies, refuse to compromise p…

The EXP Ti-lok Fitting features a two-stage locking mechanism ideal for PEEK-clad or sleeved fused silica, such as PEEKsil™ tubing. The two-stage fitting features a patented auto-adjusting titanium hybrid ferrule that seats in any port. The titanium collet locking mechanism provides a second grip point to even the pressure load over the tubing and not crush the silica. The incorporated rear collet locking mechanism is not remo…

The Intura Nitrogen & Zero Air has been developed to provide a constant and consistent source of nitrogen and zero air for detector and make-up gas for GC.

The Intura Zero Air generator is designed specifically to supply clean, dry, hydrocarbon-free air to support your GC.

The Intura Nitrogen has been developed to provide a constant and consistent source of nitrogen for detector and make-up gas for GC.

The Intura Hudrogen is designed to provide the gas needed for detectors requiring hydrogen fuel gas, such as FID and FPD as well as collision gas for ICP-MS.

The ecTOF is the world’s first GC-HRMS with simultaneous acquisition of EI (Electron Ionization) and CI (Chemical Ionization) information in a single injection. While using EI as the gold-standard GC/MS ionization, the ecTOF in parallel operates a novel CI source. This way it simultaneously provides perfectly aligned accurate mass structural and molecular ion information within a single GC run.

Validated high performance prepacked columns for scale-up and GMP biomanufacturing

Solid-phase extraction solution for bioanalysis of therapeutic oligonucleotides

EVOLUTE ABN is an advanced water-wettable polymer-based sorbent that extracts acidic, basic and neutral analytes from biological fluids and other aqueous matrices.

Advanced Polymeric SPE for Acidic Analytes

Biotage Process-Scale Flash Purification Quickly purify multi-gram quantities of organic compound Purify up to 40 grams of compound at a rate of 250 mL/min with the Biotage Flash 75™ system, up to 75% faster than traditional glass columns. These rugged stainless steel systems safely operate at 100 psi enabling higher flow rates, purity and the use of higher viscosity solvents.

Biotage—Large Scale Flash Purification

PhyTip® Gel Filtration columns are unique tools for high throughput micro volume desalting or buffer exchange applications. They represent the only high throughput, automatable, chromatography desalting solution. Unlike standard dialysis, up to 96 samples can be processed at a time in as little time as ~ 30 minutes and in most cases re-concentration is not required at the end. The gel filtration columns are similar to the P…