Robust and pH stable process chromatography material: YMC-Triart Prep
With YMC-Triart Prep, pH stable preparative HPLC stationary phases are available for industrial-scale applications. This hybrid silica-based material can be used in a pH range of 2.0 - 10.0 and allows more efficient cleaning procedures. The innovative YMC-Triart Prep combines mechanical strength and pH stability.
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To overcome the limitations of traditional silica-based stationary phases regarding the chemical stability, hybrid silica-based phases have been developed. Hybrid silica contains organic groups within the silicon dioxide network, making it more resistant to a wider pH range.
The innovative preparative stationary phase YMC-Triart Prep combines mechanical strength and pH stability. It is stable up to pH 10 which allows more flexibility for process development. Moreover, efficient cleaning-in-place (CIP) procedures can be applied!
From real-life process development examples, YMC-Triart Prep has been shown to outperform traditional silica-based materials in terms of stability up to 4-fold. Longer column lifetimes lead to greater amounts of product being produced per kilogram of stationary phase. The results mean improved production procedures and reduced overall costs.
YMC-Triart Prep Features:
- Mechanical stability
- Extended pH range
- CIP with NaOH solutions applicable
- Up to 4-fold longer lifetimes
- Compatible with SMB and SFC mode
- Available as packing material in multi-ton scale and in preparative columns
YMC-Triart Prep Characteristics:
- Phases: C18, C8, C4, Bio200 C8, phenyl
- Particle sizes: 7, 10, 15, 20 µm
- pH range: 2 - 10
- Separation modes: RP, SFC, SMB
Brochures
Hybrid silica-based stationary phases for prep LC
The increasing relevance of peptides creates special demands on the separation methods used. The large variety of peptides with different physicochemical properties requires suitable stationary phases for purification. Therefore, a selection of different phase modifications for screenings is the best solution. Additionally, the stationary phases used have to be robust, reliable, and available in large-scale quantities as well as in pre-packed column formats. Read all about the YMC-Triart Prep range in this brochure.
Purification of Peptides with Full Flexibility
Purification is the most critical step in the manufacturing process of peptide therapeutics. The right choice of chromatography media is crucial for cost-effective production. In this application note, YMC Europe GmbH's YMC-Triart Prep is used to purify liraglutide with high resolution.
