CIMmultus Oligo dT18

CIMmultus® Oligo dT columns are a breakthrough in mRNA purification. They use hybridization affinity chromatography to effectively capture mRNA. This method enables specific binding through complementary base pairing in a high ionic strength mobile phase. This ensures high purity and yield without denaturing conditions. Unlike traditional affinity resins, which have difficulty with mass transfer for larger mRNA molecules, CIMmultus® columns achieve residence times of less than 10 seconds. This allows operation at higher flow rates with minimal reduction in dynamic binding capacity (DBC). These columns deliver over 95% recovery and are effective at removing impurities, such as double-stranded RNA (dsRNA), which trigger immune responses and degrade mRNA. Due to their robust stability and exceptional scalability, CIMmultus® Oligo dT monoliths are ideal for industrial applications and large-scale mRNA production. They meet FDA and EMA standards and have full GMP documentation.

Key features:
→ Achieving up to 95% mRNA recovery, lowering manufacturing costs.
→ Operates at high flow rates and short residence times for rapid processing.
→ Removal of over 99% of process-related impurities, ensuring high purity.
→ Offers reliable ligand-based capture for precise mRNA purification.
→ Provides comprehensive support with full GMP documentation.
→ Ensures stability after chemical treatment and long-term storage.
→ Scales from micrograms to kilograms for various production stages.

Relevant applications:
→ Efficient purification of mRNA across multiple transcript lengths.
→ Ideal for mRNA therapeutics and vaccine production.
→ Suitable for facilities not equipped to work with organic solvents to support the removal of dsRNA
→ Enables rapid decision-making and process automation in mRNA production.