InertSep Oligo
InertSep Oligo is a solid-phase extraction (SPE) product for oligonucleotide purification in LC/MS workflows. It delivers high recovery, low variability, and full LC/MS compatibility. Formats include 96-well plates—Micro Elution (2 mg/400 µL) and 2 mL square-well (25 mg)—and straight barrel cartridges in multiple sizes for manual or automated high-throughput sample prep.
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InertSep Oligo is a WAX-based solid-phase extraction (SPE) product engineered for oligonucleotide sample preparation in LC/MS workflows. It delivers high recovery, low variability, and complete LC/MS compatibility—key to reliable quantitation when distinguishing parent oligonucleotides from metabolites.
Oligonucleotide therapeutics are gaining momentum for their high target specificity and low toxicity. While ligand-binding assays remain widely used, LC/MS methods are increasingly preferred in parts of development due to superior selectivity. In these workflows, robust, reproducible sample prep is essential.
InertSep Oligo supports both manual and automated high-throughput processing with multiple format options:
96-Well Plate Format
- Micro Elution: 2 mg / 400 µL
- 2 mL square-well: 25 mg / 2 mL
Straight Barrel Cartridge Format
- 10 mg / 1 mL
- 30 mg / 3 mL
- 60 mg / 3 mL
- 150 mg / 6 mL
All formats use the same WAX sorbent, ensuring consistent performance across scales and platforms
InertSep Oligo SPE
Quantifying oligonucleotide therapeutics demands high sensitivity, selectivity, and reproducible sample prep, especially in LC/MS workflows where distinguishing parent compounds from metabolites is critical.
Discover how InertSep Oligo streamlines purification with automation-ready solid phase extraction (SPE) formats, delivering consistent recovery and minimal variability. Its LC/MS-compatible sorbent ensures reliable performance across scales, supporting high-throughput nucleic acid analysis with precision.
