Zetasizer Core

Advance your development pipeline with confidence. The Zetasizer Core is the first system to combine DLS, SLS, and DSF in a single, high-throughput microwell plate workflow. By uniting key measures of stability, aggregation, and structural integrity, it delivers a complete picture of sample behaviour in one streamlined assay.

Product overview

From uncertainty to clarity. With built-in Dynamic Light Scattering, Static Light Scattering, and Intrinsic Differential Scanning Fluorimetry, the Zetasizer Core generates robust, reproducible data in a single experiment. Gain the confidence to select the right candidates, accelerate decision-making, and de-risk development at every stage.

Key features and benefits of Zetasizer Core:

• Zero proprietary consumables: needs standard microwell plates only
• 4 μL minimum sample volume (1536-well)
• 5 clicks from setup to results
• Run up to 192 samples per minute
• 35+ years of trusted Zetasizer DLS expertise results

Features that deliver results

• Exceptional data quality at scale: Industry-leading precision for confident, high-throughput decision-making
• Multi-parameter stability insights: Simultaneous measurement of size, colloidal stability, and structural stability
• Advanced thermal control: Precise knowledge of the plate’s thermal profile ensures absolute data reproducibility
• Standard plate compatibility: Seamless integration with 96-, 384-, and 1536-microwell plates
• Dedicated SLS Detector: Transforms B22 / second virial coefficient analysis from an expert-only measurement into a routine screening tool.
• Impeccable heritage: High-throughput DLS powered by the same trusted algorithms and adaptive correlation technology as the market-leading Zetasizer Advance
• Automation-ready: Designed for effortless integration into automated robotic workflows
• ZS Discover software: Intuitive interface lets users of all levels go from sample setup to results in just 5 clicks