Biozen Native RP-1
Native RP-1, developed in tandem with Native RP-5, is an advanced chromatography column designed to revolutionize ADC DAR analysis.
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Biozen Native RP-1 is a high-performance reversed-phase column engineered for robust, reliable small-molecule analysis. It delivers consistent retention, sharp peak shapes, and excellent batch-to-batch reproducibility for demanding liquid chromatography workflows.
Optimized reversed-phase performance
Biozen Native RP-1 is designed for reversed-phase separations of small molecules, providing stable retention and efficient resolution across a wide range of analytes. Its carefully controlled surface chemistry supports accurate quantitation and dependable method transfer. The column’s rugged construction helps maintain performance under routine use, supporting high sample throughput in analytical laboratories.
Reliable results for routine and advanced methods
This column is suitable for both routine quality control and more complex research applications, enabling precise profiling of small-molecule compounds. Consistent selectivity and efficiency help streamline method development and reduce rework. Biozen Native RP-1 integrates smoothly into existing liquid chromatography systems and workflows, supporting reproducible results over extended use.
Built for modern analytical laboratories
Biozen Native RP-1 supports laboratories that require dependable reversed-phase performance with minimal downtime. Its design focuses on stability, reproducibility, and ease of implementation, making it a practical choice for regulated and non-regulated environments. The column helps maintain data integrity while supporting efficient, high-quality chromatographic separations.
Key features and benefits of Biozen Native RP-1:
- High-performance reversed-phase column for small-molecule analysis
- Consistent retention and selectivity for reliable quantitation
- Robust construction for stable, long-term use in routine workflows
- Efficient peak shapes to support accurate profiling and resolution
- Compatible with modern liquid chromatography systems and methods
TechTalk: ADC characterization in one native LC-MS workflow
Friday, September 4 at 16:00 BST | 17:00 CEST | 11:00 EDT | 08:00 PDT
Achieving comprehensive antibody-drug conjugate (ADC) characterization no longer requires complex multi-step workflows. Advances in native LC-MS are creating new opportunities to simplify ADC analysis while maintaining the depth of information needed to support development decisions.
In this SelectScience® TechTalk, Roxana Eggleston-Rangel, Senior Applications Scientist at Phenomenex, will showcase how Biozen® Native RP-1 and RP-5 columns enable direct drug-to-antibody ratio (DAR) analysis through a streamlined, MS-compatible native reverse-phase liquid chromatography-mass spectrometry (RP-LC-MS) workflow.
Learn how this approach supports DAR determination, proteoform characterization, and positional isomer resolution without fraction collection or buffer exchange while maintaining native conditions.
Using case studies featuring the approved ADC therapies Enhertu®, Padcev®, Polivy®, and Adcetris®, Eggleston-Rangel will demonstrate how this workflow can be applied across a range of ADC modalities and payload chemistries. In just 20 minutes, discover how the same approach can support both high-resolution mass spectrometry and routine UV-based DAR monitoring, bringing greater efficiency and confidence to ADC characterization.
Certificate of attendance
If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes. If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.
TechTalk details
- Cost: Free to attend
- Location: Online
- Duration: 20 minutes
Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on-demand recording once it becomes available.
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Biozen Native RP-5
Phenomenex IncDeveloped alongside Native RP-1, Native RP-5 is an advanced chromatography column designed to transform ADC DAR analysis.
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