Biozen Native RP-5
Developed alongside Native RP-1, Native RP-5 is an advanced chromatography column designed to transform ADC DAR analysis.
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Biozen Native RP-5 is a high-performance reversed-phase column engineered for reliable small-molecule separations in demanding analytical workflows. It delivers consistent retention, sharp peak shapes, and robust durability for routine and advanced liquid chromatography methods.
Optimized reversed-phase performance
Biozen Native RP-5 is designed to provide stable, reproducible separations across a wide range of small-molecule analytes. Its carefully controlled stationary phase chemistry supports accurate quantitation, even for challenging compounds, while maintaining low bleed characteristics suitable for sensitive detection.
Reliable method robustness and consistency
Engineered for day-to-day reliability, this column helps minimize variability between runs and batches. The rugged construction supports extended use under typical reversed-phase conditions, helping laboratories maintain uptime and reduce the need for frequent column changes.
Versatile use in analytical laboratories
Biozen Native RP-5 integrates easily into established liquid chromatography workflows, supporting method development as well as validated routine testing. Its performance characteristics make it suitable for quality control, research, and development environments that require dependable reversed-phase separations.
Key features and benefits of Biozen Native RP-5:
- High-performance reversed-phase selectivity for small-molecule analysis
- Consistent retention and peak shape to support accurate quantitation
- Low bleed characteristics compatible with sensitive detection methods
- Robust construction for extended column lifetime and reduced downtime
- Versatile use across research, development, and quality control applications
TechTalk: ADC characterization in one native LC-MS workflow
Friday, September 4 at 16:00 BST | 17:00 CEST | 11:00 EDT | 08:00 PDT
Achieving comprehensive antibody-drug conjugate (ADC) characterization no longer requires complex multi-step workflows. Advances in native LC-MS are creating new opportunities to simplify ADC analysis while maintaining the depth of information needed to support development decisions.
In this SelectScience® TechTalk, Roxana Eggleston-Rangel, Senior Applications Scientist at Phenomenex, will showcase how Biozen® Native RP-1 and RP-5 columns enable direct drug-to-antibody ratio (DAR) analysis through a streamlined, MS-compatible native reverse-phase liquid chromatography-mass spectrometry (RP-LC-MS) workflow.
Learn how this approach supports DAR determination, proteoform characterization, and positional isomer resolution without fraction collection or buffer exchange while maintaining native conditions.
Using case studies featuring the approved ADC therapies Enhertu®, Padcev®, Polivy®, and Adcetris®, Eggleston-Rangel will demonstrate how this workflow can be applied across a range of ADC modalities and payload chemistries. In just 20 minutes, discover how the same approach can support both high-resolution mass spectrometry and routine UV-based DAR monitoring, bringing greater efficiency and confidence to ADC characterization.
Certificate of attendance
If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes. If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.
TechTalk details
- Cost: Free to attend
- Location: Online
- Duration: 20 minutes
Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on-demand recording once it becomes available.
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Biozen Native RP-1
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