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Analytical Scale Purification System

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Description

Bring your analytical purification performance to the next level

Scaling up from analytical methods to preparative methods can be uniquely challenging. The Analytical Scale Purification System is a fully automated purification solution designed for purification labs that need more efficient purification on smaller prep scales. It offers high-capacity sample processing, fraction collection, and high-pressure capabilities.

With this new solution, your lab can use smaller particle-size preparative columns and directly scale-up peak- and time-based purification to achieve more efficient and better resolution, greater precision, and higher recovery, so you can maximize sample yield and purity. Effortlessly streamline your purification workflow and accelerate drug-to-market while reducing laboratory operating costs with the Analytical Scale Purification System.

Overview

  • Achieve easier scale-up from UPLC (sub-2-µm column methods), reducing method development and scale-up time
  • Accelerate your chromatography with improved resolution and sensitivity through sub-5-µm particle-size preparative columns
  • Reduce organic solvent usage, dry-down time, waste disposal, and operating costs
  • Obtain predictable scale-up with a multi-column heating and switching column manager to increase your confidence in recovery
  • Accurately detect various small and large molecule compounds through high-performance detection capabilities, including PDA, UV/Vis, evaporative light scattering (ELS), and mass detection
  • Offer high-capacity sample processing/fraction collecting in smaller purification scales
  • Minimize sample loss and maximize information by utilizing the Isocratic Solvent Manager, which enables triple detection options (UV, ELSD, MS)
  • Benefit from an integrated offering of industry-leading chemistry and software solutions

Recommended Use: For high-capacity sample processing and fraction collection in smaller prep scales, and more efficient and cost-effective purification solutions.

Specifications

Application eBookSeparations

Mastering the fundamentals of preparative LC

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Preparative liquid chromatography (prep LC) is a cornerstone of modern purification workflows, enabling scientists to isolate target compounds from complex mixtures for research, development, and manufacturing applications. Whether supporting synthetic chemistry, analytical services, process development, or production environments, successful purification depends on balancing purity, recovery, speed, and scalability.

As purification demands grow, scientists face a range of challenges, from optimizing sample loading and scaling methods from analytical to preparative workflows, to improving productivity and overcoming common separation issues. A strong understanding of preparative LC fundamentals is essential for developing robust, efficient purification strategies that deliver reliable results.

In this SelectScience eBook, developed in partnership with Waters, explore expert insights, practical guidance, and real-world examples to help scientists build confidence in preparative chromatography. Plus, discover the key principles that underpin successful separations and learn strategies to improve purification performance across a range of applications.

Download this SelectScience guide to gain top tips on:

  • Preparing crude mixtures
  • Scaling by the rules
  • LC methods overview
  • Load considerations
  • Temperature considerations
  • Fraction collection
  • Fraction drying
  • Improving productivity
  • When things go wrong in prep

Resource details:

  • Document type: SelectScience application eBook
  • Page count: 172
  • Edition: 1st

Product Overview

Links

Analytical Scale Purification System by SelectScience - Read SelectScience Reviews