omniDAWN™ Multi-angle Light Scattering (MALS) Instrument
Delivering up to 4× faster runs with half the sample, the omniDAWN™ multi-angle static light scattering (MALS) photometer is purpose-built for UPLC™ and UHPLC systems for non-destructive absolute molar mass and size characterization of macromolecules and nanoparticles in solution.
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Delivering up to 4× faster runs with half the sample, the omniDAWN™ multi-angle static light scattering (MALS) photometer is purpose-built for UPLC™ and UHPLC systems for non-destructive absolute molar mass and size characterization of macromolecules and nanoparticles in solution. It provides exceptional sensitivity across a broad range of molecular weights, sizes, and concentrations, supported by advanced analysis modules, practical implementation guides, and intelligent system health monitoring to ensure reliable performance and streamlined workflows.
Specifications
| Measurement Mode(s) | 18 angles |
| Applications | With standard SEC/GPC or EclipseTM (FFF system): determination of distributions of molar mass, size, conformation, conjugation ratio and particle concentration. With Calypso composition-gradient system: label-free characterization of biomolecular interactions including self- and hetero-association as well as non-specific interactions. |
| Sensitivity | 10 ng of 100 kDa polystyrene in THF, under typical GPC conditions |
| 0.2 µg of BSA under a typical 30 cm column | |
| Measuring Range | 200 Da to 1000 MDa |
| Wavelength(s) | 658 nm; 785 nm available for fluorescence reduction (with lower sensitivity than 658 nm) |
| Type | MALS and optional DLS |
| Measuring Time | Depedent on LC separation |
| Radius of Gyration Range | Rg (rms radius): 10 nm to 500 nm |
| Rh (hydrodynamic radius): 0.5 nm to 300 nm or up to 1 µm (with optional DLS module; upper limit is configuration-dependent) | |
| Dimensions | (WxDxH) 36 x 60 x 23 cm |
| Detector(s) | High-gain, high-dynamic-range photodiodes at 18 angles for MALS; optional avalanche photodiode that may be placed at any of four angles for DLS. |
| Fluorescence-blocking filters available for use with analytes that fluoresce when illuminated at the MALS wavelength. | |
| Temperature Range | Ambient; Heated/Cooled (HC): -15°C to +150°C; Ultra-High-Temperature (UHT): ambient to +210°C |
| Interface | 10" high-resolution, color LCD multi-touch-screen display, and ASTRA host software |
| Sample Type | Peptides, proteins, nucleic acids, polymers, lipid nanoparticles, viruses, and other macromolecules |
| Control | Programmable 10% - 100% (laser power) |
| Light Source | 658 nm laser, programmable 10% - 100% of maximum power. |
| Optional: 785 nm for fluorescence suppression | |
| Dynamic Range | 3,300,000:1 |
