TOYOPEARL Super A Resin
TOYOPEARL Super A is a novel, robust protein A resin designed to efficiently purify mAbs and other antibody species like ADCs and bispecifics. This resin offers high alkaline stability, exceptional dynamic binding capacity, and a polymer base bead able to withstand high linear velocities.
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TOYOPEARL® Super A resin provides a cutting-edge experience in protein A media, blending top-tier critical performance attributes with exceptional operational flexibility.
An enhanced, animal-origin free, recombinant protein A ligand is bound to the polymethacrylate base bead via multipoint attachment resulting in excellent base stability for up to 100 CIP cycles with 0.5 mol/L NaOH and up to 70 CIP cycles with 1 mol/L NaOH while maintaining 90 % of its initial DBC.
TOYOPEARL Super A resin is available in ~45 µm particle size (F-grade) and exhibits dynamic binding capacities of greater than 70 g/L at 5 minutes residence time and greater than 60 g/L at 3 minutes residence time. Improved mass transfer characteristics allow it to maintain a larger percent of its capacity at lower residence times relative to comparable agarose-based resins. It is therefore ideally suited for continuous operation using multiple short columns. This resin is also available in pre-packed SkillPak columns to simplify your process development and scale-up.
Highlights
- State-of-the-art operational flexibility: Supports high titers with high dynamic binding capacity (DBC), enhanced alkaline stability for rigorous CIP, and excellent pressure flow behavior to increase process efficiency.
- Superior critical process performance: Features mild elution conditions, concentrated elution volumes, and a significant reduction in process impurities, making the process robust, safe, and compliant.
