TSKgel HIC-ADC Columns
TSKgel HIC-ADC columns are novel analytical solutions to rapidly characterize the drug-antibody ratio (DAR) for antibody drug conjugates (ADCs). Available in butyl and phenyl hydrophobicities with additions to the column family on the way, the TSKgel HIC-ADC column line has you covered for fast ADC analysis.
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The name gives it away: TSKgel® HIC-ADC columns are hydrophobic interaction chromatography (HIC) columns designed for the analysis of Antibody-Drug Conjugates (ADCs). Tosoh has developed a new particle construction to achieve exceptional separation of variably conjugated ADC variants. This next-generation breakthrough in non-porous particle technology makes DAR analysis more reliable and improves separation efficiency. The TSKgel® HIC-ADC columns set a new industry standard with respect to the following characteristics.
- Superior separation performance
- Fast analyses (e.g. DAR determination in 7 minutes)
- Reliability and lifetime
- Ligand selection for diverse molecules: Phenyl (high hydrophobicity), Butyl (mid hydrophobicity)
The columns simplify method development and tech-transfer processes for DAR analyses, enhancing both the accuracy and efficiency of Quality Control processes, and enabling the highest quality standards in ADC analysis.
