TSKgel SuperAW series columns
“Allround“ SEC-columns for initial analysis of unknown samples
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All in all a fair deal
therapeutic protein conjugate
I bought and used several columns, mainly superaw4000. different columns generated consistent results over several years and i always like to have a look into manuals which are shipped together with the columns. however, i feel that the some SEC columns are a bit overpriced
Review Date: 15 Aug 2023 | Tosoh Bioscience - Separations
Fundamental for carbohydrate research!
Carbohydrate polymers
I use a series of TSK gel super AW columns to determine Mw of carbohydrates. They are ease to install, proper for carbs analyses, and provide me with great results for my research.
Review Date: 15 Aug 2023 | Tosoh Bioscience - Separations
“Allround“ SEC-columns for initial analysis of unknown samples
For Size Exclusion Chromatography (SEC) of technical or biological polymers, Tosoh Bioscience GmbH offers a newly developed hydrophilic rigid resin showing little swelling and shrinkage in water mixtures or pure organic solvents. Small resin particles (4 µm) with narrow particle size distribution packed into 6 mm ID columns with 15 cm length demonstrate the superiority of the TSKgel SuperAW columns. Theoretical plate counts are higher and less dependent on flow rate than with conventional columns.
Five different pore sizes of the resin allow for wide Separation Ranges, e.g.100 – 1.000.000 Da (when using PEO). With a mixed-bed type column even small and very large molecules can be separated together in one run. Each column type shows a high degree of linearity for its specific calibration range. Non-SEC or mixed mode separations for small molecules are possible by selection of the eluent as demonstrated by the separation of Triton X-100 or preservatives in cosmetics.
Purification of biomolecules with chromatography techniques
Bioprocess chromatography is an effective purification technique and is key for the successful development and commercialization of new drugs, no matter whether biologic, biosimilar, or biobetter. Explore over twenty application notes covering aspects of biopharmaceutical purification such as capturing of antibody constructs, mAb aggregate removal using salt-tolerant IEC or hydroxyapatite, intermediate purification of bi-specific antibodies with a non-affinity platform using MXC and HIC, antibody-drug conjugates (ADC) purification on HIC resin, or separation of oligonucleotides on highly-selective anion exchanger.
(U)HPLC analysis of biomolecules
This compendium, from Tosoh Bioscience, compiles more than twenty application notes covering important aspects of biopharmaceutical analysis such as protein aggregation, charge isoforms and glycosylation as well as determination of drug-to-antibody ratio of antibody-drug-conjugates. The last section of the notebook provides tips and tricks to improve chromatographic separation of biomolecules.
