Kinetex Core-Shell HPLC/UHPLC Columns

In this step-by-step selectivity guide, Phenomenex provides an easy overview of the reversed phase HPLC/UHPLC options available to you. Download to understand the differences between the columns available, and select the right solution for your specific method and goals.

This application note illustrates the screening of thirty compounds encompassing seven classes of antibiotics (betalactam, tetracycline, sulfonamide, macrolide, amphenicol, fluoroquinolone, and flunixin) by LC/MS/MS using Kinetex C18. The Kinetex column simplifies the simultaneous analysis of multiple analytes by providing increased chromatographic resolution and increased sensitivity.

Monoclonal antibodies (mAbs) are well-established therapeutics for biopharmaceutical work. However, recent trends have investigated the administration of multiple mAbs for immunotherapy and passive immunization strategies. Although characterization may present unique challenges, quantitation of each individual mAb tend to rely on standard analytical workflows, but methods for drug substance of the mAb coformulation often consist of a more complex analysis. One such consideration is a simple quantitative method for the mAb coformulation.

This poster contains a HPLC selectivity reference chart to help improve LC column retention, resolution, and efficiency for your methods. The chart outlines a systematic approach for maximizing selectivity for hydrocarbons, compounds containing hydroxyl or amine functionalities, and isomers and isobaric compounds.

This application note investigates the Kinetex 2.6 µm PS C18 HPLC/UHPLC column’s improved chromatographic performance and unique multi-interaction selectivity when applied to a screen of 36 tricyclic antidepressants (TCA). Because the Kinetex 2.6 µm core-shell (superficially porous) particle morphology provides ultra-high column efficiency on any HPLC or UHPLC system, the investigation also included a comparison to a conventual fully porous 1.9 µm UHPLC column.

This product guide presents the analytical options for your laboratory's cannabis testing needs on offer from Phenomenex.

While the legalization of medical and recreational marijuana is proliferating through more and more US states, potency testing needs are also expanding as the amounts of each particular cannabinoid in a sample will impact its indication, evident by the emergence of purified, isolated cannabinoids for custom formulation. This application note demonstrates a practical chromatographic separation of 16 cannabinoids with flexibility across HPLC and UHPLC platforms in a gradient aimed for speed as well as suitability in many diverse matrices.

In this application note, Phenomenex demonstrates a method for the analysis of explosive residues found in EPA 8330A/B.

This application note sets out the challenges and preparation steps for drug detection in alternative matrices such as hair and oral fluids, simplifying methods development for performing LC-MS/MS separations for these samples.

In this technical note, Phenomenex proposes a simple and fast extraction method using Strata® DE supported liquid extraction (SLE), 400 μL 96-well plate coupled with LC-MS/MS analysis for the characterization of 25-OH Vitamin D2/D3 in human serum.

In this webinar, Dr. Stephanie Marin, Global Clinical Market Development Manager at Phenomenex, will provide a comprehensive overview of polymeric mixed-mode solid phase extraction (SPE) fundamentals and the properties of polymeric hydrophobic interaction (reversed-phase) SPE sorbents. Attendees will learn how to choose the appropriate SPE phase for their specific compounds of interest, along with an explanation of the ionic functional groups that provide the mixed-mode functionalities, including both weak and strong cation and anion exchange.

Dr. Marin will also delve into the initial extraction conditions required to initiate method development for each type of SPE sorbent, as well as specialized SPE products tailored for drug testing, phospholipid removal, and microelution SPE. This webinar will include numerous clinical research applications to exemplify these concepts.

Key learning objectives

• Discover how to differentiate different polymeric mixed-mode SPE sorbents
• Explore starting conditions for each sorbent type
• Learn how to choose the best SPE sorbent for different analytes
• Understand how to use an SPE method development plate

Who should attend?

• Scientists doing SPE method development
• Labratorians who want to increase their knowledge of polymeric mixed-mode SPE
• Lab managers who want to implement SPE methods in their laboratories

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

Watch this on-demand webinar to learn more about method development optimization for reversed-phase chromatography

Watch this on-demand webinar to learn more about method development optimization for reversed-phase chromatography

Watch the new on-demand webinar to learn more about underlying chemistry considerations for PFAS and GenX compound analysis

Alkemist Labs, an industry leader in botanical testing, highlights the importance of reliable equipment and harmonized practices in the rapidly changing cannabis landscape

Discover how superficially porous particles HPLC columns have aided the development of a new ginger rhizome reference method to support quality control testing of the popular food supplement

Learn how a laboratory in the United States is using highly sensitive chromatography approaches to measure the tiniest amounts of the latest synthetic chemicals contaminating our food, clothes and environment

Find out how the Sanitation Districts of Los Angeles have developed new methods for analyzing contaminants in sediment samples

SelectScience speaks to Dr. B.J. Bench of Tyson Foods to learn about the separations technology advancing food and animal nutrition testing for food safety and quality assurance

Labcyte Inc., Wyatt Technology Corp., Erlab Inc., Specac and Bertin Instruments among the recipients as more top-rated products gain a coveted SelectScience Seal of Quality

Program is 'invaluable' for scientists needing to make informed purchasing decisions for their lab