A Comparison of the Kinetex C18 Core-Shell Column’s Performance in Comparison to a Conventionally Fully Porous UHPLC Column
18 Jul 2019This application note investigates the Kinetex 2.6 µm PS C18 HPLC/UHPLC column’s improved chromatographic performance and unique multi-interaction selectivity when applied to a screen of 36 tricyclic antidepressants (TCA). Because the Kinetex 2.6 µm core-shell (superficially porous) particle morphology provides ultra-high column efficiency on any HPLC or UHPLC system, the investigation also included a comparison to a conventual fully porous 1.9 µm UHPLC column.
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Kinetex 2.6 µm PS C18
Phenomenex IncThe new Kinetex 2.6 µm PS C18 phase is beneficial for all types of compounds (acids, bases, neutrals), but especially for the analysis of polar basic compounds. The phase has demonstrated increased polar analyte retention, improved peak shape for troublesome basic analytes under typical reversed phase conditions, and a unique multi-modal interaction selectivity making it indispensable tool for multi-compound and metabolite profile screens.
