Single Cellome™ Unit SU10 by Yokogawa Electric Corporation

SU10 is a nanopipette-based tool for efficient and controlled delivery of material (such as CRISPR Cas9 complex, RNA, proteins) into the nucleus or cytoplasm of single cells in a highly automated manner. The CRISPR Cas9 complex can be delivered directly into the nucleus of a specific target cell in a minimally invasive manner through the utilized glass pipette in nanometer range (approx.100 nm).


Single Cellome™ Unit SU10 by Yokogawa Electric Corporation product image
Single Cellome™ Unit SU10

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SU10 is a nanopipette-based tool for efficient and controlled delivery of material (such as CRISPR Cas9 complex, RNA, proteins) into the nucleus or cytoplasm of single cells in a highly automated manner. The CRISPR Cas9 complex can be delivered directly into the nucleus of a specific target cell in a minimally invasive manner through the utilized glass pipette in nanometer range (approx.100 nm). Especially the delivery of material into cells that are hard-to-transfect can be a benefit by using SU10.

Key features

  • Low Invasiveness:  Glass pipette with tip size of under 100 nm
  • Automated Penetration: Automated cell surface detection and penetration (Z direction movement)
  • Automated Injection: Automated, controller volume injection using electro-osmotic flow
  • High Success Rate: Approx. 95% success rate of injection*3
  • Single-Cell Targeting: Enabled injection of selected cells under microscope observation
  • Rapid Injection: Capable of injecting one cell every 10 seconds*3

*1 Function to aspirate intracellular substances is under development.
*2 Microscope sold separately.
*3 Experiment by Yokogawa.

Applications

  • Direct injection of substances such as vector and genome editing tools (CRISPR/Cas9) into the nucleus
  • Efficacy/toxicity evaluation of drug candidate molecules
  • Other physical injection of reagents and proteins 
  • Inject into cells that cannot be introduced by conventional methods 
  • Analysis of cell-cell communication starting from the injected cell