Brain-Derived Tau (BD-Tau) Luminescence Immunoassay
The Brain-derived Tau (BD-Tau) LUM is a sensitive and accessible research-use only blood assay. Combining a specific antibody targeting brain-derived Tau with upfront immunoprecipitation, BD-Tau LUM offers researchers a powerful and accessible tool to investigate Alzheimer's disease pathology, progression, and biomarker dynamics in plasma.
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The Human BD Tau Luminescence Immunoassay is an enzyme immunoassay intended for the quantitative determination of brain derived TAU protein from peripheral cell free body fluids as blood plasma or serum after enrichment of BD Tau using the BD-Tau Neuro IP Kit (30260912).
The Tau protein is a microtubule-stabilizing protein being part of the axons of nerve cells in the central nervous system (CNS). Measuring total Tau in CSF reflects axonal destruction and has found its way into diagnostic criteria guidelines¹, but measuring total Tau in blood does not correlate with its corresponding CSF value. As 80% of Tau in blood originates from peripheral tissue, being able to selectively measure the brain-derived fraction will enhance specificity and accessibility of Tau as an AD biomarker. The antibody used in the BD-Tau LUM is targeting the brain-derived Tau isoform only.
Automated BD-Tau and p217 Tau analysis on the Fluent 780 Workstation
This Tecan application note presents a fully automated workflow for enriching and quantifying brain-derived Tau (BD-Tau) and phosphorylated p217 Tau from blood samples using the Fluent® 780 Workstation. By integrating immunoprecipitation with luminescence-based measurement, the workflow supports reliable analysis of blood-based biomarkers relevant to Alzheimer’s disease and neurodegenerative disease research.
Discover how the automated protocol reduced hands-on time from more than four hours to just 20 minutes per 96-well plate. It also improved precision compared with manual processing, showed no significant plate drift, and enabled BD-Tau and p217 Tau measurement from the same enriched eluate.
Resource details
Resource type: Application note
Page count: 9
Read time: 14 mins
