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Automated BD-Tau and p217 Tau analysis on the Fluent 780 Workstation

Tecan
2 Sept 2026

This Tecan application note presents a fully automated workflow for enriching and quantifying brain-derived Tau (BD-Tau) and phosphorylated p217 Tau from blood samples using the Fluent® 780 Workstation. By integrating immunoprecipitation with luminescence-based measurement, the workflow supports reliable analysis of blood-based biomarkers relevant to Alzheimer’s disease and neurodegenerative disease research.

Discover how the automated protocol reduced hands-on time from more than four hours to just 20 minutes per 96-well plate. It also improved precision compared with manual processing, showed no significant plate drift, and enabled BD-Tau and p217 Tau measurement from the same enriched eluate.

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Resource type: Application note
Page count: 9
Read time: 14 mins

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Fluent® Laboratory Automation Workstation

Tecan

Tecan has reinvented automation with the Fluent Laboratory Automation Workstation, a unique instrumentation concept built around the application-specific needs of your laboratory. Fluent breaks new ground, delivering more capacity and increased speed. It provides superior precision, throughput and walkaway time, making it easier to get more done, more confidently.

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Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Alzheimer's diseaseAlzheimer's researchAlzheimer's disease is a neurodegenerative condition characterized by progressive memory loss and cognitive decline. Research focuses on understanding the molecular and cellular mechanisms of the disease, as well as developing effective treatments and diagnostic tools. Browse our peer-reviewed product directory to find the best Alzheimer's research products, compare options, check reviews, and get pricing directly from manufacturers.Disease BiomarkersNeuroscienceNeuroscience research investigates the neurological mechanisms underlying behavior, neurodegenerative diseases, and other brain conditions. Learn about the innovative technologies for bioimaging, electrophysiology, cell culture, chromatography and other techniques used in this field.Tau

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