p217 Tau Luminescence Immunoassay
The p217 Tau LUM is a sensitive research tool that together with an upfront BD-Tau immunoprecipitation allows for the measurement of p217 BD-Tau in blood samples.
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The Tau protein is a microtubule-stabilizing protein being part of the axons of nerve cells in the central nervous system (CNS). Measuring total Tau in CSF reflects axonal destruction and has found its way into diagnostic criteria guidelines¹, but measuring total Tau in blood does not correlate with its corresponding CSF value. As 80% of Tau in blood originates from peripheral tissue, being able to selectively measure the brain-derived fraction will enhance specificity and accessibility of Tau as an AD biomarker.
p217 Tau has been shown to correlate with the Amyloid-beta pathology in Alzheimer's disease patients and can discriminate between so-called amyloid-beta-positive and amyloid-beta-negative patients (determined by CSF amyloid-beta measurement)
Automated BD-Tau and p217 Tau analysis on the Fluent 780 Workstation
This Tecan application note presents a fully automated workflow for enriching and quantifying brain-derived Tau (BD-Tau) and phosphorylated p217 Tau from blood samples using the Fluent® 780 Workstation. By integrating immunoprecipitation with luminescence-based measurement, the workflow supports reliable analysis of blood-based biomarkers relevant to Alzheimer’s disease and neurodegenerative disease research.
Discover how the automated protocol reduced hands-on time from more than four hours to just 20 minutes per 96-well plate. It also improved precision compared with manual processing, showed no significant plate drift, and enabled BD-Tau and p217 Tau measurement from the same enriched eluate.
Resource details
Resource type: Application note
Page count: 9
Read time: 14 mins
TechTalk: Automated measurement of BD-Tau and BD-p217-Tau in blood
Friday, October 16 at 15:00 BST | 16:00 CEST | 10:00 EDT | 7:00 PDT
Accurate measurement of brain-derived Tau (BD-Tau) and phosphorylated Tau (BD-p217 Tau) in blood is becoming increasingly important in Alzheimer’s disease and neurodegeneration research. However, established manual workflows can be time-consuming and may introduce variability, making it more difficult to achieve consistent, reproducible results.
In this SelectScience® TechTalk, join Oliver Schmidt, Tecan, to discover how two key neurodegeneration biomarkers, BD-Tau and BD-p217 Tau, can be applied on the TECAN Fluent® 780 instrument. He will explore their role in neurodegeneration research and demonstrate how automated workflows can support more efficient and consistent biomarker measurement.
You will gain practical insight into the application of BD-Tau and BD-p217 Tau assays, the advantages of moving away from manual procedures, and how automation can help streamline blood-based biomarker analysis for Alzheimer’s disease research.
Certificate of attendance
If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes. If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.
TechTalk details
- Cost: Free to attend
- Location: Online
- Duration: 20 minutes
Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available
