Denarase®

Denarase^® is a recombinant Serratia marcescens endonuclease used for efficient removal of residual DNA and RNA in bioprocessing. Available in R&D- and GMP- grade, Denarase® supports process development through commercial manufacturing with comprehensive regulatory documentation and technical support.

Benefits of Denarase^®:

• High activity to all forms of DNA/RNA
• Designed to support efficient nucleic acid clearance and competitive process economics
• Available in R&D- & GMP-grade with identical specifications
• Denarase^® GMP-grade is produced under GMP conditions in accordance with EU GMP regulations
• Manufacturing free of animal derived materials and antibiotics
• Endotoxin-free expression host
• One-for-all Serratia marcescens ELISA Kit
• Comprehensive technical & regulatory support, e.g. drug master file for US-market approvals

Denarase^® is a trusted endonuclease for residual nucleic acid removal, widely adopted by biopharma companies across development, clinical, and commercial manufacturing workflows. Customers rely on Denarase^® for its proven performance, reliable supply, and comprehensive regulatory and technical support. For customers evaluating Denarase^® as a new endonuclease or as an alternative to an existing nuclease, Kerry provides guidance documents to support qualification, process implementation and supplier change assessments.