Denarase® High Salt
Salt-active GMP endonuclease for DNA removal in high-salt viral vector manufacturing workflows
Place your order directly with the manufacturer.
Denarase® High Salt is engineered from Denarase® for an improved salt and pH profile, while maintaining its specificity for nucleic acids. Denarase® High Salt demonstrates superior activity compared with alternative salt-active nucleases under process-relevant conditions and provides maximal flexibility in process design.
Benefits of Denarase® High Salt:
- High activity to all forms of DNA/RNA
- Strong DNA removal performance from 0–500 mM salt
- Supports competitive process economics and process flexibility for high-salt biomanufacturing workflows
- Available in R&D- & GMP-grade with identical specifications
- Denarase® High Salt GMP-grade is produced under GMP conditions in accordance with EU GMP regulations
- Manufacturing free of animal derived materials and antibiotics
- Endotoxin-free expression host
- Compatible with the one-for-all Serratia marcescens ELISA Kit
- Comprehensive technical & regulatory support
Denarase® High Salt is gaining strong traction across the biopharma industry, with growing adoption from early evaluation through process development and GMP manufacturing. Customers value its proven performance, reliable supply, and the comprehensive technical, qualification, and regulatory support that accompanies its use.
Brochures
Guidance on how to qualify Denarase enzymes in biopharmaceutical manufacturing processes
The selection and qualification of raw materials, such as Denarase® and Denarase® High Salt, for biopharmaceutical manufacturing is a comprehensive and complex process. This product brochure supports customers in the qualification of Denarase® enzymes for the production of cell and gene therapy products and human vaccines, while outlining the support services provided by Kerry throughout the qualification process.
Resource details:
Resource type: Product Brochure
Page count: 6
Read time: 10 min
Unlocking flexibility in Viral Vector Manufacturing: High-efficiency DNA removal – engineered to fit your process
This poster highlights how Denarase® High Salt enables efficient DNA removal across a wide range of salt concentrations used in viral vector manufacturing, supporting greater process flexibility, improved viral vector yields, and enhanced downstream purification. It also shows that Denarase® High Salt delivers superior performance over other salt-active endonucleases at process-relevant pH 7.4 and provides recommendations on which Denarase® enzymes are best suited for different operating conditions.
Resource details:
Resource type: Scientific Poster
Page count: 1
Read time: 4 mins
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