Denarase® High Salt
Salt-active GMP endonuclease for DNA removal in high-salt viral vector manufacturing workflows
Denarase® High Salt is engineered from Denarase® for an improved salt and pH profile, while maintaining its specificity for nucleic acids. Denarase® High Salt demonstrates superior activity compared with alternative salt-active nucleases under process-relevant conditions and provides maximal flexibility in process design.
Benefits of Denarase® High Salt:
- High activity to all forms of DNA/RNA
- Strong DNA removal performance from 0–500 mM salt
- Supports competitive process economics and process flexibility for high-salt biomanufacturing workflows
- Available in R&D- & GMP-grade with identical specifications
- Denarase® High Salt GMP-grade is produced under GMP conditions in accordance with EU GMP regulations
- Manufacturing free of animal derived materials and antibiotics
- Endotoxin-free expression host
- Compatible with the one-for-all Serratia marcescens ELISA Kit
- Comprehensive technical & regulatory support
Denarase® High Salt is gaining strong traction across the biopharma industry, with growing adoption from early evaluation through process development and GMP manufacturing. Customers value its proven performance, reliable supply, and the comprehensive technical, qualification, and regulatory support that accompanies its use.










