Guidance on change to Denarase in approved biopharmaceutical manufacturing processes

24 Aug 2026

Denarase® is an endonuclease enzyme used in biopharmaceutical manufacturing to remove unwanted nucleic acids, making it a critical component of the production process. This product brochure supports customers transitioning from an alternative endonuclease to Denarase® in approved manufacturing processes as part of a post-approval change. It also outlines the support provided by the Kerry Biotechnology Center to facilitate an efficient and successful implementation.

Resource details:

Resource type: Product Brochure
Page count: 3
Read time: 5 mins

Denarase®

Kerry

GMP Serratia marcescens endonuclease for residual DNA removal in viral vector, vaccine and biologics manufacturing

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EnzymesEnzymes are macromolecular biological catalysts used across life science, pharmaceutical and clinical research. Various enzymes can be purchased for research applications including ligases, high fidelity polymerases, nuclease, protease, restriction enzymes, tissue dissociation enzymes and enzyme inhibitors. Find the best enzymes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.