From endonuclease comparability challenges to harmonized activity testing

18 Aug 2026

The comparability of endonucleases is essential to secure supply chains, including dual sourcing strategies. In this study, the Denarase® activity release test developed by Kerry (formerly c-LEcta) for its Denarase® product is used, to compare activities of Denarase® and Benzonase®. By applying the Denarase® activity release assay test protocol to both enzymes, the correspondence of these results to the respective product's CoA values was evaluated.

Resource details:

Resource type: Scientific Poster
Page count: 1
Read time: 4 mins

Denarase®

Kerry

GMP Serratia marcescens endonuclease for residual DNA removal in viral vector, vaccine and biologics manufacturing

(0)

Links

Tags

EnzymesEnzymes are macromolecular biological catalysts used across life science, pharmaceutical and clinical research. Various enzymes can be purchased for research applications including ligases, high fidelity polymerases, nuclease, protease, restriction enzymes, tissue dissociation enzymes and enzyme inhibitors. Find the best enzymes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.