Raptor™ Biphenyl LC Column by Restek Corp.

Manufacturer Restek Corp.
4.8
/
5.0
  |  17 reviews
With Raptor™ LC columns, Restek chemists became the first to combine the speed of superficially porous particles (also known as SPP or “core-shell” particles) with the resolution of highly selective USLC® technology. This new breed of chromatographic column allows you to more easily achieve peak separation and faster analysis times without expensive UHPLC instrumentation. SPP core-shell columns commonly employ traditional phenyl-hexyl stationary phases, but the innovative Biphenyl ligand, devel... Read more


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Raptor™ Biphenyl LC Column
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Average Rating: 4.8
17 Scientists have reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money


  • Status:

    Reviewer
  • Member since: 2021

  • Organization: Anzac research institute



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Best separation for isomers. Fantastic.
Rating: 4.3

  • Application Area: Steroid analysis

"It's easy to set up my method and the after sales support is helpful. It's worth the money in every aspect."

Review date: 09 Feb 2021 | Raptor™ Biphenyl LC Column
  • Status:

    Advanced Reviewer

  • Member since: 2017

  • Organization: Liberty Pharma Inc



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Excellent performance, robust, reproducible and reliable. A++.
Rating: 5.0

  • Application Area:Bioanalytical testing applications like drug and metabolite analyses

"This column recommended and shared by our Restek representative became extremely useful in analyzing and resolving analytes/derivatives that were hard to resolve or elute early on other C18 and phenyl columns we tried."

Review date: 24 Dec 2020 | Raptor™ Biphenyl LC Column
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Forensic & Analytical Science Service



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great performer.
Rating: 5.0

  • Application Area:Analytical chemistry

"Raptor Biphenyl LC columns are very versatile and suitable for analysis of a wide range of drugs including very polar molecules such as morphine and codeine glucuronides. "

Review date: 24 Dec 2020 | Raptor™ Biphenyl LC Column
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: American Ordnance



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great column life!
Rating: 5.0

  • Application Area:UHPLC/MS/MS Column

"Best column life we have found! Restek columns have saved us so much money by not needing to order a new one every three months like other columns we've used. Very stable and easy to use, absolutely great all around!"

Review date: 03 Mar 2020 | Raptor™ Biphenyl LC Column
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Southwest Lab Albuquerque NM



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great column for urine drug testing.
Rating: 5.0

  • Application Area:Clinical lab

"The Raptor HPLC column for urine drug testing give good resolution and consistent RT from column to column. We get approximately 5000 injections per column."

Review date: 09 Dec 2019 | Raptor™ Biphenyl LC Column
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Anzac research institute



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Happy with results & support.
Rating: 4.7

  • Application Area:Serum analysis for steroids

"This biphenyl column has been great for my steroids application, it’s helped me achieve separation for isobaric steroids improving specificity."

Review date: 09 Dec 2019 | Raptor™ Biphenyl LC Column
  • Status:

    Advanced Reviewer

  • Member since: 2019

  • Organization: Access Medical Laboratories



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    3 out of 5
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Very good separation, fit perfectly to our application.
Rating: 4.3

  • Application Area:Oral fluids testing

"The application notes are very concise, though not a lot of details are shared."

Review date: 09 Dec 2019 | Raptor™ Biphenyl LC Column
  • Status:

    Advanced Reviewer

  • Member since: 2019

  • Organization: Buckeye Clinic



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great results, Can't complain.
Rating: 5.0

  • Application Area:Drug analysis

"We achieve high quality seperation and reproducibilty for drug analysis with Raptor Biphenyl 2.7 uM 100 x 2.1 uM columns. It's easy to install and change."

Review date: 09 Dec 2019 | Raptor™ Biphenyl LC Column
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Wake Spine and Pain Specialists



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Amazing results. Great lifespan.
Rating: 5.0

  • Application Area:Analyze parent drugs and metabolites

"These columns are by far the best I have used. They are very easily installed and produce high quality chromatographs on our 3200 LC/MS/MS. The lifespan of these columns is amazing. Columns are our most expensive consumable, but far and away we are able to inject more samples with this column compared to other brands."

Review date: 09 Dec 2019 | Raptor™ Biphenyl LC Column
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Interventional Pain Specialists



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Great column, consistent results
Rating: 4.0

  • Application Area:Analyze drugs of abuse in urine samples

"Our laboratory has been using the Raptor Biphenyl LC Column for over 5 years now with minimal to no problems. Easy to change and reproduces consistent results day after day. Very happy with Restek services and products."

Review date: 12 Apr 2019 | Raptor™ Biphenyl LC Column


  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Alliance Laboratories



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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I wouldn't use anything else in my LC for toxicology
Rating: 5.0

  • Application Area:Clinical Toxicology

"I love the raptor column, they are rugged, efficient, and with proper care and use, can last a long time. They are perfect for separation of drugs and metabolites and are easy to install and condition on the rare day that its lifetime ends. Their long lasting nature makes life easy as they provide value per unit and decrease downtime, since I do not need to condition a new column every other month."

Review date: 12 Apr 2019 | Raptor™ Biphenyl LC Column
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Aspenti Health



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Quality product!
Rating: 5.0

  • Application Area:Clinical drug testing

"This product provides reliable chromatography results, and is easy to connect and use. Resolution is excellent."

Review date: 12 Apr 2019 | Raptor™ Biphenyl LC Column
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Hart Biologicals



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great consumables and service.
Rating: 5.0

  • Application Area:HPLC analysis of epinephrine

"After speaking to Raptor experts at Thames Restek we agreed on a evaluation period for the Raptor Biphenyl column for HPLC analysis of small molecules. The service they provided was excellent and they have offered after care support, allocating meetings at our place of work."

Review date: 11 Apr 2019 | Raptor™ Biphenyl LC Column
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Deakin University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great alternative to C18 column
Rating: 5.0

  • Application Area:Monitoring reaction products

"This column has been a very useful alternative to C18 columns for the separation of polar compounds and difficult to separate isomers. So far the results have been reproducible and we haven't encountered any problems using this column."

Review date: 12 Jul 2018 | Raptor™ Biphenyl LC Column
  • Status:

    Reviewer

  • Member since: 2015

  • Organization: Alison Wicker - University of Texas at Arlington



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Efficient column for use in SFC
Rating: 5.0

  • Application Area:Multiple applications by SFE-SFC

"We are currently building a repertoire of columns to use in SFC for multiple applications. We've had some success with separating PAH & metabolites using the 150 mm x 4.6 mm x 2.7 u Raptor Biphenyl column, as well as fat soluble vitamins. This column allows us to operate at high flow rates for fast separations. Excellent customer service!"

Review date: 23 Mar 2017 | Raptor™ Biphenyl LC Column
  • Status:

    Reviewer

  • Member since: 2015

  • Organization: Department of Forensic Science, Laurentian University



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
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As promised, this column does a better job of resolving our analytes from matrix constituents than the traditional C18 chemistry we were using.
Rating: 4.7

  • Application Area:Analysis of post-mortem tissues for drugs and metabolites

"As promised, this column does a better job of resolving our analytes (antipsychotic drugs) from matrix constituents (post-mortem - decomposed - bone tissue extracts) than the traditional C18 chemistry we were using. We are using PDA detection, where chromatographic resolution is much more critical than with MS detection. As a result we are using the 150 mm x 2.1 mm column (1.7 um) particle size."

Review date: 22 Jun 2015 | Raptor™ Biphenyl LC Column
  • Status:

    Advanced Reviewer

  • Member since: 2010

  • Organization: Ernest Jackson



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Rating: 4.0

  • Application Area:HPLC Analysis Of Pharmaceuticals

"This offers an interesting alternative to C18 and complex mobile phases for some difficult separations. It appears to have advantages over phenyl-hexyl, and with more experience, I may use the Raptor as my generic phase of first choice. It has good efficiency, allowing the possibility of shorter run times. It is well worth investigating for troublesome applications."

Review date: 27 Jan 2014 | Raptor™ Biphenyl LC Column
With Raptor™ LC columns, Restek chemists became the first to combine the speed of superficially porous particles (also known as SPP or “core-shell” particles) with the resolution of highly selective USLC® technology. This new breed of chromatographic column allows you to more easily achieve peak separation and faster analysis times without expensive UHPLC instrumentation.

SPP core-shell columns commonly employ traditional phenyl-hexyl stationary phases, but the innovative Biphenyl ligand, developed by Restek’s chemists, is the next generation of phenyl column chemistry. It provides greater aromatic selectivity than commercially available phenyl-hexyl columns[1] and a greater degree of dispersion than conventional phenyls. As a result, the Raptor™ Biphenyl allows you to more easily separate bioanalytical compounds like aromatics, which elute early or are hard to separate on C18 or other phenyl chemistries.

One of the greatest advantages of an SPP column is the ability to achieve fast, efficient separations by operating at higher linear velocities than are possible with a convbentiaonal fully porous particle column. However this can also result in higher back pressures. Raptor™ columns were designed to handle the increased pressures needed to achieve Selectively Accelerated, and handle it far better than other SPP columns on the market.


Raptor™ Biphenyl LC Column Features & Benefits:

  • Higher efficiency for drastically faster analysis times.
  • Better selectivity for substantially improved resolution.
  • Increased sample throughput with existing HPLC instrumentation.
  • Ideal for bioanalytical testing applications like drug and metabolite analyses.
  • Heightened selectivity and retention for compounds that are hard to resolve or elute early on C18 and other phenyl chemistries.
  • Limits ionization suppression and allows simple, MS-friendly mobile phases.
  • Restek's most popular LC stationary phase applied to Raptor™ SPP core-shell silica.

Column Details:

  • Stationary Phase Category: Phenyl (L11)
  • Ligand Type: Biphenyl
  • Particle: 2.7um SPP
  • Pore Size: 90 Å
  • Surface Area: 150 m2/g
  • Length: 30 - 150 mm
  • ID: 2.1, 3.0, 4.6 mm