A Novel Solution for Vitamin K₁ and K₂ Analysis in Human Plasma by LC-MS/MS
28 Feb 2019Vitamin K₁ and K₂ analysis is typically complex and time-consuming because these lipophilic vitamins occur at low levels and are subject to matrix interference, particularly from phospholipids. The new method established here provides fast, accurate, and precise vitamin K analysis in plasma, using a simple phospholipid removal procedure and a sensitive, 4-minute LC-MS/MS analysis on a Raptor Biphenyl column, making it suitable for both research and high-throughput testing.
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Raptor™ Biphenyl LC Column
Restek Corp.With Raptor™ LC columns, Restek chemists became the first to combine the speed of superficially porous particles (also known as SPP or “core-shell” particles) with the resolution of highly selective USLC® technology. This new breed of chromatographic column allows you to more easily achieve peak separation and faster analysis times without expensive UHPLC instrumentation.