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Bio-based vs. conventional methanol for analytical HPLC workflows – A comparative performance study

Merck
17 Sept 2026

Sustainable laboratory practices are becoming increasingly important across pharmaceutical research, development, and quality control. High-performance liquid chromatography (HPLC) workflows consume large volumes of methanol, creating an opportunity to reduce environmental impact without compromising analytical performance.

Explore how LiChrosolv® BioRenewable methanol can reduce the carbon footprint of routine HPLC workflows while maintaining the performance expected from conventional solvents. Delivering approximately 21.4% lower carbon dioxide-equivalent (CO₂e) emissions and comparable chromatographic performance across key United States Pharmacopeia (USP) methods, it provides a practical route to more sustainable analysis. This means laboratories can take meaningful steps towards their sustainability goals without disrupting established methods or the reliable data quality their HPLC workflows depend on.

Resource details:

Resource type: Application note
Page count: 14
Read time: 21 mins

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.SustainabilitySustainability in research and industry focuses on reducing environmental impact, conserving resources, and promoting long-term ecological balance. Innovations in sustainable practices include renewable energy, waste reduction, and eco-friendly materials. Explore more sustainabile solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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