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LC troubleshooting - All of my peaks are tailing! What should I do?
27 Apr 2021
Tailing peaks can be a problem when doing liquid chromatography (LC), and secondary silanol interactions are one of the causes. Here, using the example of basic drugs, Restek explains what causes them and cover a few steps that can be taken to minimize the effect of these secondary silanols on peak shape when troubleshooting.
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Raptor™ Biphenyl LC Column
Restek Corp.With Raptor™ LC columns, Restek chemists became the first to combine the speed of superficially porous particles (also known as SPP or “core-shell” particles) with the resolution of highly selective USLC® technology. This new breed of chromatographic column allows you to more easily achieve peak separation and faster analysis times without expensive UHPLC instrumentation.
