Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer
The Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer enables real-time, accurate spectral results for process monitoring. MarqMetrix All-In-One Process Raman Analyzer redesigns how Raman spectroscopy brings value to the Process Analytical Technology workflow by focusing on a user-centric experience through its rapid setup, portability, and ease of use for upstream and downstream R&D applications.
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The Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer is a compact, portable Raman spectrometer. This all-in-one system is purpose-built for rapid deployment, ease of use, and scalability in markets with critical time-to-results.
The MarqMetrix All-In-One Process Raman Analyzer offers:
• Analysis without sample preparation, delivering Raman spectral results in real-time
• Easy setup and deployment by non-Raman spectroscopists
• Nondestructive workflows to protect precious samples
• Noninvasive handling to minimize contamination of samples
• Small footprint for convenient deployment
• Factory calibration for hardware stability and portability
With the MarqMetrix All-In-One Process Raman Analyzer, businesses can conduct real-time, nondestructive, and immediate analysis without sample preparation. This analyzer makes precise and accurate measurements simple to execute and understand with its one-button hardware and easy-to-use software. The analyzer is designed for out-of-the-box use, enabling you to collect highly accurate Raman measurements in less than 15 minutes. Pack this analyzer in a protective case and take it to the point of need, as its factory calibration ensures continuous and precise analysis on the go. The analyzer can be easily integrated into your existing process, eliminating the need for costly technical expertise.
Brochures
Process Raman spectroscopy for downstream applications in oil and gas industries
In the downstream sector, accurate and timely data is critical. Traditional methods, like knock engines and gas chromatography, can take hours, delaying important decisions. With Raman spectroscopy, onsite labs can streamline analysis processes through real-time data, enhancing quality assurance and operational efficiency. Find out how process Raman spectroscopy enhances efficiency in refinery onsite labs by providing real-time analysis for gasoline blend certification and more. Plus, explore a case study of a US-based refinery using the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer, which enables real-time certification of rack batches while generating custody transfer documentation.
Process Raman spectroscopy for cultivated meat applications
With the global population on the rise, the demand for sustainable, efficient, and environmentally friendly protein sources has never been more urgent. Cultivated meat is revolutionizing the approach to protein consumption, presenting a promising alternative.
Raman spectroscopy technology offers opportunities for cultivated meat producers, enhancing productivity and accelerating time-to-market. By optimizing bioreactor utilization and minimizing waste from suboptimal batches, Process Raman spectroscopy empowers producers to achieve unprecedented efficiency and maximize their operational potential. Explore the advantages of the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer and its role in supporting sustainable cultivated meat solutions.
Process monitoring from raw materials to finished products in biopharma
As part of current good manufacturing practice (cGMP), many pharmaceutical manufacturers are adopting process analytical technologies (PAT), quality by design (QbD), or process validation (PV) to provide continuous process verification and analysis. Analytical instruments may be used for at-line and in-process monitoring to bring the technology to the sample to speed up the analysis process and enable more flexibility from a smaller footprint. Discover efficient process monitoring solutions in biopharmaceutical production with Thermo Scientific analyzers and bioreactors.
Portable spectroscopy with MarqMetrix All-In-One Process Raman Analyzer
Discover the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer. This compact and portable spectrometer provides real-time, non-destructive Raman analysis without the need for sample preparation. Designed for ease of use, the system offers a simple setup, noninvasive workflows, and factory calibration for consistent performance. Explore its practical features, including intuitive software and straightforward integration into existing processes, making it a versatile solution for various industries.
Using a process Raman analyzer as an in-line tool for accurate protein quantification in downstream processes
Therapeutic proteins are used to treat a variety of conditions and diseases such as cancer, immunologic diseases, communicable diseases like COVID-19, and many others. Thus, ensuring the quantity and quality of therapeutic proteins throughout the manufacturing is of paramount importance.
Explore a study that was carried out that measured mAb concentration using the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer. Discover how this in-line process analytical technology (PAT) solution enables real-time monitoring that reduces batch-to-batch variability to support product uniformity.
PAT-enabled scaling and optimization of upstream bioprocesses
Scaling up a bioprocess is a complex, multi-variable challenge. Designing processes with scalable parameters is essential for ensuring confidence when transitioning from the research laboratory to clinical and production operations. Explore how modern bioreactors and process Raman technology can enhance bioprocess development and enable advanced process control strategies from pilot to production scale.
From spectrum to power: Advanced spectroscopy in battery production
Understanding the component materials and chemical processes of high-performance batteries is essential for optimizing their efficiency and safety. Vibrational spectroscopy techniques, such as FTIR and Raman, provide critical insights into the composition, structure, and bonding of battery materials. From analyzing raw lithium resources to monitoring internal electrodes and recycled components, these techniques enable real-time assessment throughout battery production. Explore how Thermo Fisher Scientific's vibrational spectroscopy tools support lithium-ion battery manufacturing at every stage.
Oil and gas process analysis terminology
Accurate measurement is essential in the oil and gas industry. Understanding the chemical composition of raw materials and the consistency of processed products can create a competitive advantage at every point in the process. Explore a list of the essential process analytics terminology. Master precise chemical composition and process consistency measurement in the oil and gas industry with Raman spectroscopy. From exploration to distribution, optimize every stage with accurate, real-time data using advanced analytical tools like the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer.
Accelerating the analysis of refined fuel properties using a novel solid state Raman analyzer
Refinery laboratories must analyze hundreds of samples per day. In a medium size refinery, this can be 250 samples per day and in a large refinery, the number can be as high as 500 per day. The current analytical tools conventionally used are gas chromatographs, simulated distillation, flash & freeze point devices, densitometers, vapor pressure testers, test engines for RON & MON and many others.
Solid state Raman spectroscopy can measure multiple properties of gasoline, jet and diesel fuels accurately, precisely and rapidly in a matter of seconds. In this paper, Thermo Scientific™ will describe the methodology for collecting high quality Raman spectroscopy spectra and the strategy for turning the spectral data into actionable information to inform critical decision-making processes.
Maximize efficiency and quality in cultivated meat production
Cultivated meat, also known as cell-based or lab-grown meat, represents an innovative and emerging field of food technology. In this process, meat products are grown from animal cells in a controlled laboratory environment without the need for traditional animal farming. This emerging field has gained significant interest due to its potential to address various environmental, ethical, and sustainability challenges associated with conventional meat production.
In this study, Thermo Scientific™ present a proof of concept (PoC) study for monitoring glucose and lactate in cultivated meat production using a Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer, in collaboration with Ivy Farm Technologies within one of their bench-scale processes.
Using process Raman spectroscopy in cultivated meat production
Cultivated meat, also known as lab-grown meat or cell based meat, is a rapidly growing industry that aims to provide a sustainable and ethical alternative to traditional animal agriculture. While the technology for producing cultivated meat has advanced significantly in recent years, there is still much to be done to optimize the production process and ensure consistent quality of the final product. One technology that has shown promise in addressing these challenges is Raman spectroscopy. Raman spectroscopy is a non-destructive analytical technique that can be used to identify and quantify the chemical composition of a sample. This makes it an ideal tool for analyzing the complex biological components of cultivated meat. In this application note, Thermo Scientific™ cover the seven benefits of using Raman spectroscopy for cultivated meat production.
Monitor and maintain glucose concentrations in real time
Process analytical technology (PAT) enables manufacturers to measure and control a process based on the product’s critical quality attributes (CQAs) in real time. In recent years, process Raman spectroscopy has gained popularity as a PAT tool that enables real-time monitoring and control of critical bioprocessing parameters which are key to the successful production of therapeutic drugs. Implementing PAT tools in biopharmaceutical manufacturing continues to receive much interest, allowing rapid development and access to therapeutics and existing medications without compromising high quality.
In this study, the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer with Thermo Scientific™ Lykos™ PAT Software and Thermo Scientific™ TruBio™ 6.0 Bioprocess Control Software was used to provide in-line feedback control of glucose in both Fed-Batch and Perfusion CHO cell culture processes without the need for operator intervention.
Combine chemometric models with MarqMetrix All-In-One Process Raman Analyzer
The MarqMetrix™ All-In-One Process Raman Analyzer is a Raman spectroscopy instrument designed to offer rapid, robust, scalable, and reliable identification, quantification, and characterization of molecules during any phase of R&D process development. It is an “all-in-one” instrument utilizing easily exchangeable, autoclavable probes to meet the various analytical needs for, but not limited to, upstream bioprocess monitoring, or characterization of fill and finish products.
In this study, Thermo Scientific™ demonstrates the transferability of a complex chemometric model evaluating three relevant analytes: glucose, glutamine and lactate using the MarqMetrix™ All-In-One Process Raman Analyzer.
Raman spectroscopy and the MarqMetrix All-In-One Process Raman Analyzer
Given the complex nature of biologically derived products, there is a need for improved process control in biopharmaceutical manufacturing. Limited visibility into real-time reactions has posed challenges to quality and yield. Discover how the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer addresses this by providing a compact, user-friendly, and portable solution that uses Raman spectroscopy for precise, rapid, and non-destructive analysis. This enables operators to effectively monitor critical process variables, enhancing control and product quality in various manufacturing environments.
Unlocking the potential: Raman spectroscopy as real-time Process Analytical Technology (PAT) for automation and enhanced bioproduction
Feb 12, 2025 – 15:00 GMT / 16:00 CET / 10:00 ET / 7:00 PT
Real-time analytics using in-line and on-line technologies provide valuable insights into bioprocess parameters and cell-feeding strategies. Leveraging Process Analytical Technology (PAT), bioproduction processes can be optimized to deliver exceptional results. This includes developing scalable and transferrable processes in monoclonal antibody (mAb) bioproduction. PAT is a game-changer in the bioproduction industry, empowering manufacturers to stay ahead in a highly competitive market.
Join Dr. Nimesh Khadka, a senior R&D scientist at Thermo Fisher Scientific, as he discusses how PAT in bioproduction is revolutionizing how premium products can be developed and manufactured. He will also explore the benefits of the implementation of PAT in bioproduction, including improved process efficiency, reduced manufacturing costs, and the ability to deliver high-quality products consistently.
Key learning objectives
- Learn what the advantages are of Raman Spectroscopy as Process Analytical Technology (PAT)
- Explore case studies that show the implementation of Raman as PAT for upstream and downstream processes
- Understand how to use chemometrics as a tool to extract useful information from the complex matrix
- Discover how the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer is a reliable, scalable, and accurate instrument with minimum inter-instrument variability allowing model transferability across instruments
Who should attend?
- Process engineers
- PAT scientists
- Process development & team leaders
- R&D team leaders
- Process improvement champions
- Those working in cell culture/bioproduction
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
Connecting at-line UV-Vis with in-line process Raman for real-time protein and excipient monitoring
Tuesday, December 9 at 15:00 GMT | 16:00 CET | 10:00 EST | 07:00 PST
Accurate measurement of protein as well as excipient concentration is essential in downstream biopharmaceutical manufacturing and process control, spanning from post-purification stages to final preparation for fill and finish.
Join Dr. Janam Pandya and Patrick Brown as they explore how UV-Vis and Raman spectroscopy work together to deliver a complete picture of bioprocess performance. Learn how rapid, at-line UV-Vis analysis provides precise quantification of highly concentrated protein samples, while complementary, in-line Raman spectroscopy continuously monitors protein concentration and excipients in real time.
By integrating these two optical techniques, scientists can connect fast at-line confirmation with continuous in-line insight, enabling data-driven decisions that enhance process understanding, control, and product quality.
Key learning objectives:
- Understand how UV-Vis and Raman spectroscopy complement one another across at-line and in-line workflows.
- Learn how a new at-line UV-Vis technology enables accurate measurement of highly concentrated protein samples.
- Discover the strengths of process Raman spectroscopy in quantifying protein concentration and excipients in complex matrices.
- Explore how process Raman spectroscopy can be applied for in-line analysis to support process decision-making.
Who should attend?
- Scientists developing standard operating procedures (SOPs) and improving manufacturing processes, including upstream/downstream, MSAT, and PAT roles.
- R&D and technical experts exploring new technologies including lab managers, QA/QC, professors, engineers, and purchasing agents.
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
