Using a process Raman analyzer as an in-line tool for accurate protein quantification in downstream processes

9 Dec 2025

Therapeutic proteins are used to treat a variety of conditions and diseases such as cancer, immunologic diseases, communicable diseases like COVID-19, and many others. Thus, ensuring the quantity and quality of therapeutic proteins throughout the manufacturing is of paramount importance.

Explore a study that was carried out that measured mAb concentration using the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer. Discover how this in-line process analytical technology (PAT) solution enables real-time monitoring that reduces batch-to-batch variability to support product uniformity.

Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer

Thermo Fisher Scientific

The Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer enables real-time, accurate spectral results for process monitoring. MarqMetrix All-In-One Process Raman Analyzer redesigns how Raman spectroscopy brings value to the Process Analytical Technology workflow by focusing on a user-centric experience through its rapid setup, portability, and ease of use for upstream and downstream R&D applications.

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Using a process Raman analyzer as an in-line tool for accurate protein quantification in downstream processes