Novum Simplified Liquid Extraction (SLE)

Novum SLE (patent pending) eliminates the questions associated with diatomaceous earth. As a lab-manufactured sorbent, you can expect reliable, more consistent results. Download this guide to find out more.

This application note aims to help you improve your methods for more effective and quicker bioanalytical sample preparation.

The world is changing and we need to widen our Environmental Scope. Although analytical techniques and established regulated methods are not easily changed; more complex targets, larger lists, and a variety of sample matrices create a daily challenge for environmental chemists. By using the latest technologies and techniques in HPLC/ UHPLC and Sample Preparation, laboratories and chemists are able to develop better approaches to make their work Faster, Cheaper and Easier. Phenomenex is committed to supporting the industry through a comprehensive product portfolio of Sample Preparation, HPLC/UHPLC, and LC-MS, columns and accessories, along with application and method development services to meet industry needs.

This application note discusses sample preparation techniques for a variety of clinical samples for simplified liquid extractions (SLE) and solid phase extraction (SPE).

This clinical notebook contains a variety of 36 application notes, covering topics in endocrinology and biomarker research, therapeutic drug monitoring, toxicology and sample preparation.

This application note provides guidance on selecting a sample preparation technique for food testing and examples of experiments that use the techniques, which include QuEChERS, Simplified Liquid Extraction and Solid Phase Extraction. The article also includes ordering information for the required Phenomenex products.

Sample preparation is crucial in achieving desired LC or GC analytical results. Sample matrix effects can result in an array of interferences which can lead to poor chromatography as well as instrumentation drawbacks, hindering your approach and goal for the analysis. This application note provides guidance on how to choose your sample preparation solution and techniques for filtration, protein precipitation, phospholipid removal, simple liquid extraction and solid phase extraction.

Supported Liquid Extraction (SLE) has been developed as an alternative sample preparation method to remedy some of the drawbacks of liquid-liquid extraction. Recent advances have introduced Novum Simplified Liquid Extraction products which are packed with a unique, synthetic SLE sorbent that alleviates the challenges associated with a natural resource. This case study was performed on a steroid panel with a specific focus on betamethasone to demonstrate two effective ways to increase recovery using the novel Novum synthetic SLE material.

Corticosteroids exhibit anti-inflammatory properties and are widely abused within the sports industry. Chromatographic separation is essential for detection and confirmation of corticosteroids because cortisone and prednisolone are isomeric compounds. A simple automated extraction method using Phenomenex’s Novum Simplified Liquid Extraction (SLE) is employed to extract corticosteroids from plasma samples. A Kinetex 2.6 μm Biphenyl HPLC/UHPLC column is used to successfully separate these two compounds.

Marijuana is one of the most popularly used drugs in the world. THC is the most potent psychoactive compound in marijuana and is banned in many countries. In the human body THC is metabolized to form a hydroxylated compound and COOH-THC. The carboxylic form and the conjugated glucuronic acid are excreted in urine. The aim of this application note is to introduce a fast and effective sample preparation technique using Novum Simplified Liquid Extraction products that overcomes the challenges observed in a traditional liquid-liquid extraction.

Learn how you can simplify your liquid extractions by using Novum Simplified Liquid Extraction (patent pending) products, a faster, easier, and more reliable liquid extraction solution. Novum is the first synthetic SLE product that overcomes the challenges associated with diatomaceous earth SLE.

Novum Simplified Liquid Extraction (SLE) (patent pending) 96-well plates are a FASTER, EASIER, and MORE RELIABLE way to perform liquid-liquid extractions. In 3 easy steps and less than 15 minutes, you can remove unwanted interferences such as salts, proteins, and phospholipids from biological samples without performing extensive method development.