The Clinical Application Notebook: Edition 2
12 Sept 2017This clinical notebook contains a variety of 36 application notes, covering topics in endocrinology and biomarker research, therapeutic drug monitoring, toxicology and sample preparation.
This clinical notebook contains a variety of 36 application notes, covering topics in endocrinology and biomarker research, therapeutic drug monitoring, toxicology and sample preparation.


Z-Guard columns are universal GC guard columns, designed for use with virtually any GC capillary column, from virtually any manufacturer. Features: Extends column lifetime by preventing stationary phase damage Improves separation, peak shapes (especially early elutors), sensitivity, and accuracy of quantitative results

Used under HILIC running conditions, this phase provides the highest polar selectivity for retention and separation of hydrophilic compounds.

Highly reproducible pentafluorophenyl phase exception for halogenated, conjugated, isomeric, or highly polar compounds.

Aromatic and moderate hydrophobic selectivity result in the great retention and separation of aromatic hydrocarbons.

100% aqueous stable reversed phase chemistry with hydrophobic, aromatic, and enhanced polar selectivity.

Moderate hydrophobic and steric selectivity is offered, bringing ultra-high performance to USP L7 and other octyl silane methods.

Balanced C18 phase that provides the highest degree of hydrophobic selectivity relative to the other Kinetex phases.

This unique C18 phase yields increased hydrogen bonding with hydrophobic selectivity, resulting in improved peak shape for basic compounds and increased retention of acidic compounds.

Novel pH 1-12 stable C18 that delivers robust methods and improved peak shape for bases.

β-Gone β-Glucuronidase Removal 96-well plates and tubes are designed to target and remove β-glucuronidase from hydrolyzed urine samples without requiring additional time or method development. In a single step and in less than 1 minute, your hydrolyzed samples are ready for analysis. In Under a Minute You Can Easily: Increase HPLC/UHPLC Column Lifetime Reduce Mass Spec Maintenance Maintain the Selectivity of Your HPLC/UHPLC Column

Robust, Accurate Polymeric Solid Phase Extraction (SPE) Products


Simplify Your Liquid-Liquid Extractions with Faster, Easier, and More Reliable SLE

SecurityGuard Guard Cartridge System Column Protection is designed to fit any manufacturers’ standard HPLC column, making it the ultimate HPLC Guard Column.

Quick, Easy, Cheap, Effective, Rugged for multiresidue pesticide clean-up



SecurityGuard ULTRA offers a convenient and economical way to extend core-shell, sub-2µm, and other UHPLC column lifetimes SecurityGuard™ ULTRA dramatically extends UHPLC column lifetime and is ideal for virtually any manufacturer's UHPLC, sub-2µm or core-shell columns. SecurityGuard ULTRA protects against the damaging effects of chemical contaminants and microparticulates introduced by the sample, mobile phase or system, which can negatively impact column lifetime, method sensitivity, quantitation and peak identification. By reducing the frequency of column replacements, as well as the need for troubleshooting and system down time, SecurityGuard ULTRA saves chromatographers time and money. Pressure-rated up to 20,000 psi (1,378 bar), these guard cartridges have no significant impact on chromatography, backpressure or dead volume. To watch how easy it is to install SecurityGuard ULTRA visit the product webpage. SecurityGuard ULTRA provides the following advantages: Virtually no change in chromatography Easy cartridge replacement Universal fit compatible with majority of UHPLC column endfittings Pressure rated up to 20,000 psi. Phenomenex also offers an interactive web application where users can enter their UHPLC, sub-2µm or core-shell column information to find the most appropriate column protection system. Visit the interactive selection tool at www.phenomenex.com/guardit

Strata-X Drug B and N Solid Phase Extraction (SPE) sorbents are designed and quality control tested for basic and neutral drugs of abuse analysis, respectively. The sorbents are QC tested using drug probes from urine samples so that you can have confidence in your results. The sorbents also do not require conditioning/equilibrating steps, saving both time and solvent.

Impact™ protein precipitation plates with Solvent Shielding Technology™ offer a rapid and convenient way to remove proteins from plasma and tissue homogenate samples prior to analysis.The Solvent Shielding Technology design will withhold organic solvents above the filter membranes for up to 25 minutes, allowing for direct in-well precipitation upon sample addition. The precipitate is then filtered out via vacuum, centrifuge or positive pressure resulting in a clean, protein depleted extract.

Available retention mechanisms include reversed phase, ion exchange, normal phase and mixed mode

SecurityGuard offers a convenient and economical way to extend HPLC column lifetimes. Did you know a common cause of high backpressure, split peaks, broad peaks, baseline noise, baseline drift and loss of resolution is contaminants? The fact is all mobile phases contain some chemical contaminants or microparticulates, from the sample, solvent, or wear on the polymeric seals of the pump or injector. These contaminants can clog frits, irreversibly bind to an HPLC column, degrade performance, and even damage the flow cell. SecurityGuard™ is a universal HPLC guard cartridge system designed to effectively (and inexpensively), protect all your valuable analytical columns from the damaging effects of chemical contaminants, without altering your chromatographic results. SecurityGuard cartridge system provides the following advantages: Universal Phases, No Change in Chromatography Universal Fit Provides Universal Compatibility Direct-view Feature for Easy Changing Ease of Cartridge Selection Phenomenex also offers an interactive web application where users can enter their HPLC column information to find the most appropriate column protection system.

Extends UHPLC, HPLC, SFC, and PREP column lifetime