DynaPro™ NanoStar™ II Dynamic Light Scattering Detector
The DynaPro™ NanoStar™ II DLS instrument determines size and molar mass with as little as 2 µL of solution.
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It gives an answer in a very short time with small amounts of samples.
characterize protein sizes
It is simple to use, doesn't require a lot of sample. It gives results in a very short time.
Review Date: 27 Mar 2023 | Waters | Wyatt Technology
Reliable data set.
Analyze the size and PDI of nanoparticles in colloidal state
As a bionanoengineer, I prepare a wide range of polypeptide based nanostructures for their biomedical applications. I have used another machine also for size measurement but this equipment is very sensitive as it can detect very minute levels of polydispersity in the sample which makes it a good equipment for size measurements.
Review Date: 20 Jul 2021 | Waters | Wyatt Technology
Easy to use. Excellent service.
Analyze protein fiber formation and molecular weights
The instrument is very easy to set up and use. The credits from instrument purchase for attending lighting school is really helpful to master measurements.
Review Date: 27 May 2020 | Waters | Wyatt Technology
Great product, fantastic service, amazing company
analyze crystallographic samples
The machine is excellent for sample characterization and intermolecular interaction assays (we work on RNA and protein interactions). The service engineers and Wyatt corporate have been outstanding and have bent over backwards to help our newly established laboratory with software, hardware, and user issues.
Review Date: 5 Jan 2017 | Waters | Wyatt Technology
I would recommend this instrument as must have for full protein characterization
protein characterization
We are using this instrument to characterize our protein product. It is an essential tool for analytical and formulation to make decision on the go/no go project
Review Date: 23 Dec 2016 | Waters | Wyatt Technology
Great and simple result giving interface
Protein analysis prior to crystallization
Great instrument giving clear results in short time. Temp controlling makes it easy to estimate temp for crystallization and potential protein aggregation. Kd analysis helps to modify ionic strength of the buffers. Connection easy to set up to computer in case your computer crashes. Wyatt staff very helpful in troubleshooting and analysis of results. After sale care is very good. You will not be left alone after warranty expires.
Review Date: 22 Dec 2016 | Waters | Wyatt Technology
Very user friendly, high-throughput size measurements
Measure the size and temperature stability of nanoparticles
Very easy to use, you just enter a few values and make a spreadsheet with sample IDs, then press 'Go'. When you come back you have a plate full of data.
Review Date: 20 Dec 2016 | Waters | Wyatt Technology
My core lab is unthinkable without Wyatt LS instruments!
Analyze variety of protein and peptide solutions and nanoparticles
I am a Wyatt products customer since 1999, and all of them I had were of top quality
Review Date: 29 Jun 2016 | Waters | Wyatt Technology
The DynaPro™ NanoStar™ II is a unique cuvette-based DLS instrument used for the analysis of proteins, gene therapy vectors, viruses and virus-like particles, promiscuous inhibitors, micelles, liposomes, lipid, and metallic nanoparticles, and more. To accommodate scarce and precious samples, specially designed quartz cuvettes afford robust, accurate measurements with as little as 2 µL of solution, while our proprietary disposable cuvettes provide comparable sensitivity with as little as 4 µL
Walk-up operation with DYNAMICS® Touch™
The NanoStar is the only DLS instrument to provide a fully integrated, walk-up measurement experience. No need to boot up your lab PC, launch the DLS software, connect to the instrument and worry about where your data files are stored. DYNAMICS Touch is an intuitive—yet capable—DLS measurement app that resides right on the NanoStar. Via the full-size touch screen display, DYNAMICS Touch guides you through the entire setup and measurement process. It tells you if the data quality is sufficient for confidence in the results, and displays them instantly. Data files and concise PDF reports can be stored on the instrument, transferred via the network or downloaded to a flash drive. You can even send the report to your phone!
Features:
- Sensitivity: 0.1 mg/mL of 14.4 kDa lysozyme
- Hydrodynamic radius (Rh) range: 0.2 – 2500 nm
- Molar mass range: 300 Da – 1 MDa
- Temperature control: heated/cooled -10 to +120°C,
- Minimum sample requirement: 2 µL in quartz microcuvette, 4 µL in disposable microcuvette
- Optional infrared laser wavelength to eliminate fluorescence
- Can connect via optical fiber to a MALS detector for simultaneous online MALS and DLS measurement with size exclusion chromatography (SEC) or field-flow fractionation (FFF)
- Touch-panel display for immediate access to data, diagnostics and settings
- Software: DYNAMICS® analysis software offers comprehensive analysis of size and size distributions, molar mass, diffusion interaction parameter kD, second virial coefficient A2, thermal behavior Tagg/Tm/Tonset, DLS-based viscosity; full export of all results; optional 21CFR11 support for GMP
Applications:
- Size, aggregation and stability of small molecules, peptides, proteins, vesicles, nanoparticles, quantum dots and low/sub-micron colloids
- Protein quality control for interaction or structural studies
- Protein and polymer weight-average molecular weight
- Macromolecular interactions: diffusion interaction parameter kD and second virial coefficient A2 (B22)
- Thermal onset parameters Tagg, Tonset, Tm
- Solubility of polymers
- Critical micelle concentration and temperature
- Nanoparticle structure by combining MALS and DLS sizing
A biopharmaceutical workflow powered by Wyatt Technology
Reliable biophysical characterization is a cornerstone of biologics development, playing a critical role at every stage – from selecting promising drug candidates to optimizing formulations and ensuring consistent manufacturing processes. Explore a comprehensive guide on how to deliver biopharmaceutical solutions, beginning with light scattering technology.
Particle size analysis by DLS for optimization of protein complexes for measurement by small-angle neutron scattering
Explore how dynamic light scattering (DLS) can be used to ensure monodispersity in protein samples for small-angle neutron scattering (SANS) studies. Discover how researchers using the DynaPro™ Plate Reader, detected protein aggregation that was undetectable by SDS-PAGE and UV spectroscopy. This method enhances sample quality assessment, ensuring reliable SANS measurements for studying Type I bacterial restriction-modification systems.
Characterization of AAV-based viral vectors by DynaPro DLS/SLS instruments
In this application note, Wyatt Technology explores the utilization of the DynaPro Plate Reader and DynaPro NanoStar instruments for the quantification of three quality attributes (QAs) of AAV drug products: aggregate content, thermal stability, and total viral particle concentration. These two technologies, which combine dynamic light scattering (DLS) and static light scattering (SLS) respectively, represent low-volume, quick-screening tools for quantifying AAV quality attributes.
Influence of heating rates on the thermostability characterization of antibodies by DLS and SLS
In this application note, the DynaPro® NanoStar® was used to study the impact of ramp rate on the apparent thermostability of trastuzumab (Her-ceptin), a commercially available mAb applied in the treatment of breast cancer. This study examined the effects of heating rate on the measured value of Tonset.
pH effects on stability and homogeneity of a protein complex analyzed by DLS
In this application note, the Wyatt DynaPro® dynamic light scattering (DLS) system was used to characterize the homogeneity and stability of heterodimeric protein complex (HPC) under various buffer conditions.
Screening developability and pre-formulation of biotherapeutics with high-throughput dynamic light scattering
As the pharmaceutical industry targets increasingly complex biologic candidates, automated formulation and analytical workflows play an important role in streamlining the development process. Explore the technology that powers automated high-throughput dynamic light scattering (HT–DLS) and its practical applications in candidate and formulation selection. Capable of performing 96 runs in under 45 minutes and 384 wells in 1.5–2 hours, with completely unattended operation, discover how high-performance HT–DLS accelerates analysis time, reduces the need for expert operator supervision, and improves confidence in data quality.
Organic-phase encapsulation in protein-based nanocapsules studied by DLS
In this application note, Wyatt Technology utilizes dynamic light scattering (DLS) and the DynaPro NanoStar DLS/SLS instrument to investigate protein-based nanocapsule formulation and dispersion properties based on particle size.
