Agilent 1260 Infinity II Bio-Inert LC System
The 1260 Infinity II Bio-Inert LC is a dedicated solution for analysis of large biomolecules in biological samples, including monoclonal antibody (mAb) and protein analysis. Metal-free components in the sample flow path and the absence of iron and steel in solvent delivery lines ensure the integrity of your biomolecules, minimize unwanted surface interactions, and increase column lifetime.
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Review of service
Basic research in the university
Very good service by Agilent. Really knowlegable and helpful field engineers.
Review Date: 27 Nov 2024 | Agilent Technologies
This system is our work horse in the lab and it is used daily.
Analyzed lipid metabolites in the ocular system
The re-producibility and consistency of this system is excellent for variety of samples, in addition to the sensitivity.
Review Date: 23 Mar 2023 | Agilent Technologies
Maximum performance is achieved in combination with the company's TOF-MS.
Biopharmaceuticals
This new model is specialized for biopharmaceutical analysis and is the best system for macromolecular separation. Conducted training using actual biopharmaceutical solutions with great care. Cheaper than other products of the same grade.
Review Date: 11 May 2022 | Agilent Technologies
Instrument condition is always good and always Great Result for our samples
Cell toxicity for organic compounds
Agilent Korea have convenience service system for us. and they always care to customers through sales employee.
Review Date: 5 May 2022 | Agilent Technologies
Reliable, value for money, robust.
Mab detection
Easy to use, user training applicable, We used infinity 1260 module for mab detection. Process development is easy.
Review Date: 16 Nov 2021 | Agilent Technologies
It’s easy to use, and convenient.
Biological products
As for biological products, for QC lab it’s a great and easy to use system. It does not need much time to understand the features and it’s so convenient. The only downside is that we needed another detector which is not an Agilent instrument.
Review Date: 24 Jul 2020 | Agilent Technologies
The 1260 Infinity II Bio-Inert LC is a dedicated solution for analysis of large biomolecules in biological samples, including monoclonal antibody (mAb) and protein analysis. Metal-free components in the sample flow path and the absence of iron and steel in solvent delivery lines ensure the integrity of your biomolecules, minimize unwanted surface interactions, and increase column lifetime.
The power range of the 1260 Infinity II Bio-inert LC expands from low pressure for traditional biopurification columns up to high pressure for sub-2-micron analytical biocolumns. Agilent Buffer Advisor software facilitates faster pH scouting and easy buffer/solvent preparation for ion exchange chromatography.
Features:
- The metal-free sample flow path at 600 bar offers a reliable analysis of biological samples means that none of your precious sample touches metal surfaces, minimizing unwanted surface interactions while increasing column lifetime
- Inert flow cells for UV and fluorescence detection and inert solvent and column selection valves for multimethod/multi-attribute analysis offer instrument variaty for highest adaptability
- High salt tolerance (2 M) and wide pH range (1–13, short term 14) with active seal wash and quaternary solvent blending offer increased flexibility
- The 1260 Infinity Bio-Inert Multisampler is designed for low carryover using multiwash capability, to reduce carryover to less than 9 ppm
- Novel bio-inert capillary and connection design and InfinityLab Quick Connect/Quick Turn column fittings offer ease of use
- Faster pH scouting and easy buffer/solvent preparation for ion exchange chromatography with Agilent Buffer Advisor software simplifying bioanalysis workflows and reducing the time for buffer preparation
- Upgrade to Multi-Detector Bio-SEC Solution for reproducible advanced analysis of accurate molecular weights and size information of protein-based pharmaceuticals
- AdvanceBio column portfolio for SEC, IEX, reversed-phase LC, and peptide mapping for highest flexibility
Fast, high-resolution size exclusion chromatography of aggregates in biotherapeutics
In this application note, Agilent Technologies describes techniques to increase sample throughput without compromising the accuracy of analysis and demonstrates the advantages of using shorter Agilent AdvanceBio SEC columns and higher flow rates to significantly increase throughput for the analysis of aggregates in biotherapeutic proteins.
High-throughput and sensitive size exclusion chromatography (SEC) of biologics using Agilent AdvanceBio SEC Columns
In this application note, Agilent Technologies demonstrates the use of shorter and narrower Agilent AdvanceBio SEC columns for fast, high-resolution, sensitive, and reproducible separation and quantitation of monoclonal antibodies (mABs) and antibody drug conjugate (ADC).
Analysis of monoclonal antibodies: Using multiple heart-cutting hydrophobic interaction/reversed phase 2D-LC-MS
A particular downside of hydrophobic interaction chromatography (HIC) is that the high proportion of nonvolatile salt used to drive the separation makes it completely incompatible with LC-MS. In this application note, Agilent Technologies overcome this obstacle using a 2D-LC system, which affords multiple heart-cutting and subsequent desalting/separation using reversed-phase chromatography on-line with TOF MS.
Titer determination
In this application compendium, Agilent Technologies explores titer determination and presents a ‘how-to’ guide for affinity chromatography. Download the eBook to explore methods for determining monoclonal antibody concentrations utilizing the Agilent Bio-Monolith Protein A column.
N-glycan analysis: Better together
In this brochure, Agilent Technologies introduces the Agilent and ProZyme sample preparation workflows that are designed to help push your glycoprotein analysis to new levels of performance.
Charge variant analysis
In this application compendium, Agilent Technologies presents a ‘how-to’ guide for ion-exchange chromatography for biomolecule analysis. It includes application notes demonstrating how to refine your charge variant analysis of monoclonal antibodies and how analysis times can be significantly reduced, increasing throughput without compromising analytical performance.
AdvanceBio HIC: A hydrophobic HPLC column for monoclonal antibody variant analysis
Monoclonal antibodies (mAbs) and related products such as antibody-drug conjugates (ADCs) and bispecific antibodies (bsAbs) are the fastest-growing classes of biotherapeutics.This application note demonstrates the separation of oxidized mAb variants from their native form using the Agilent AdvanceBio HIC column.
Charge variant and aggregation analysis of innovator and biosimilars of rituximab
Monoclonal antibodies are an important class of biomolecules used for the treatment of various diseases. Biosimilars, the copy versions of an innovator molecule, need to be characterized in detail for their critical quality attributes such as aggregates and charge variants. This application note compares two rituximab biosimilars from different manufacturers to the innovator for their aggregation and charge variant profiles by following two analytical workflows using Agilent 1260 Infinity II Bio-Inert LC and Agilent AdvancedBio columns.
Agilent InfinityLab Bio-inert LC Solution: True Bio-Inertness for Efficient Biomolecule Analysis
The Agilent InfinityLab Bio-inert LC Solution is a complete, 100 percent bio-inert solution designed for unmatched confidence in your biomolecule analysis.
Comparison of Biosimilar and Innovator Monoclonal Antibody Rituximab
This study investigated the monoclonal antibody rituximab and its use in biotherapeutics. The physicochemical and biological characterization of a biosimilar rituximab was carried out using an Agilent 1260 Bio-inert LC system, Bio-columns, and Agilent OpenLAB CDS Match Compare Software tool.
Purify Your Way with Better Solutions for Compound Isolation
In this video discover how to purify your way with Agilent’s comprehensive portfolio of high-instrumentation, columns, software and services to ensure the highest purity and maximum recovery.
Overcome protein aggregation analysis challenges and gain confidence in your results
Discover solutions for high-resolution, high-throughput size exclusion chromatography analysis of protein therapeutics
