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Fast, high-resolution size exclusion chromatography of aggregates in biotherapeutics

15 Jul 2021

In this application note, Agilent Technologies describes techniques to increase sample throughput without compromising the accuracy of analysis and demonstrates the advantages of using shorter Agilent AdvanceBio SEC columns and higher flow rates to significantly increase throughput for the analysis of aggregates in biotherapeutic proteins.

Agilent 1260 Infinity II Bio-Inert LC System

Agilent Technologies

The 1260 Infinity II Bio-Inert LC is a dedicated solution for analysis of large biomolecules in biological samples, including monoclonal antibody (mAb) and protein analysis. Metal-free components in the sample flow path and the absence of iron and steel in solvent delivery lines ensure the integrity of your biomolecules, minimize unwanted surface interactions, and increase column lifetime.

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Fast, high-resolution size exclusion chromatography of aggregates in biotherapeutics