AdvanceBio HIC: A hydrophobic HPLC column for monoclonal antibody variant analysis

27 Jun 2021

Monoclonal antibodies (mAbs) and related products such as antibody-drug conjugates (ADCs) and bispecific antibodies (bsAbs) are the fastest-growing classes of biotherapeutics.This application note demonstrates the separation of oxidized mAb variants from their native form using the Agilent AdvanceBio HIC column.

Agilent 1260 Infinity II Bio-Inert LC System

Agilent Technologies

The 1260 Infinity II Bio-Inert LC is a dedicated solution for analysis of large biomolecules in biological samples, including monoclonal antibody (mAb) and protein analysis. Metal-free components in the sample flow path and the absence of iron and steel in solvent delivery lines ensure the integrity of your biomolecules, minimize unwanted surface interactions, and increase column lifetime.

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AdvanceBio HIC: A hydrophobic HPLC column for monoclonal antibody variant analysis