Drug discovery > Pre-Clinical Development Products & Reviews

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Products, services, reviews and techniques used in lead molecule delivery, formulation and toxicology, using assays and animal models.

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ROS-Glo™ H2O2 Assay

Promega Corp.

The ROS-Glo™ H2O2 Assay is a homogeneous, fast and sensitive bioluminescent assay that measures the level of hydrogen peroxide (H2O2), a reactive oxygen species (ROS), directly in cell culture or in defined enzyme reactions.   This assay allows identification of conditions or test compounds, such as small molecule inhibitors or inducers, that alter ROS levels. The scalable multiwell format couples a stable luminescent si…

5.0/5.0
|2 Reviews
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CellTiter-Glo® Luminescent Cell Viability Assay

Promega Corp.

The CellTiter-Glo® Luminescent Cell Viability Assay(a,b) is a homogeneous method of determining the number of viable cells in culture based on quantitation of the ATP present, an indicator of metabolically active cells. The CellTiter-Glo® Assay is designed for use with multiwell formats, making it ideal for automated high-throughput screening (HTS), cell proliferation and cytotoxicity assays. The homogeneous assay procedure in…

4.7/5.0
|22 Reviews
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CellTiter-Glo® 2.0 Assay

Promega Corp.

The CellTiter-Glo® 2.0 Assay provides a homogeneous method for determining the number of viable cells in culture by measuring the amount of ATP present, which indicates the presence of metabolically active cells. The CellTiter-Glo® 2.0 Assay is based on the original CellTiter-Glo® Assay chemistry but with improved storage convenience for easy implementation. The CellTiter-Glo® 2.0 Assay is provided as a single, ready-to-use re…

4.9/5.0
|3 Reviews
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Lactate-Glo® Assay

Promega Corp.

The Lactate-Glo™ Assay is a bioluminescent assay for rapid, selective and sensitive detection of L-lactate in biological samples. Lactate is produced by glycolysis, a major metabolic pathway responsible for glucose homeostasis and energy production (1,2). Once considered merely a byproduct of glycolysis, lactate is now considered an important regulatory molecule of intermediate metabolism involved in cancer development, diabet…

5.0/5.0
|1 Review
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Digitonin

Promega Corp.

Digitonin can be used in cell viability and cytotoxicity assays. It is a detergent solution useful for permeabilizing cells and for creating a cytotoxicity chemistry positive control. Supplied at 20mg/ml in DMSO

5.0/5.0
|1 Review
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CellTiter 96® AQueous One Solution Cell Proliferation Assay (MTS)

Promega Corp.

The CellTiter 96® AQueous One Solution Cell Proliferation Assay is a colorimetric method for determining the number of viable cells in proliferation, cytotoxicity or chemosensitivity assays. The CellTiter 96® AQueous One Solution Reagent contains a tetrazolium compound [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt; MTS(a)] and an electron coupling reagent (phenazine ethos…

5.0/5.0
|2 Reviews
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GSH-Glo™ Glutathione Assay

Promega Corp.

The GSH-Glo™ Glutathione Assay is a luminescence-based assay for the detection and quantification of glutathione (GSH). The assay is based on the conversion of a luciferin derivative into luciferin in the presence of glutathione, catalyzed by glutathione S-transferase (GST). The signal generated in a coupled reaction with firefly luciferase is proportional to the amount of glutathione present in the sample. Luminescence is gen…

5.0/5.0
|3 Reviews
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NT8® v4

FORMULATRIX®, Inc.

Reliable Drop Setting: Reduce Costs + Increase Reproducibility The NT8 ® - Drop Setter/Crystallization Robot is a fast, nanoliter-volume liquid handler with drop dispensing capability, including setting drops for Lipidic Cubic Phase (LCP) experiments. The 8-tip head aspirates and dispenses drops from 10 nL to 1.5 μL.

4.9/5.0
|2 Reviews
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MANTIS® Liquid Dispenser

FORMULATRIX®, Inc.

The MANTIS automated liquid dispenser excels at accurate, low-volume dispensing in a wide variety of scientific workflows. The system is an easy and affordable solution to quickly increase the reproducibility and quality of your research as well as the throughput and efficiency of your laboratory. 

4.6/5.0
|24 Reviews
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FORMULATOR®

FORMULATRIX®, Inc.

Build Crystallization Screens with Ease The FORMULATOR ® - Screen Builder is a next-generation liquid handler specifically designed for Protein Crystallography that uses patented microfluidic technology to dispense up to 34 different ingredients to design even the most complex optimization screens. A 96-nozzle dispensing chip can dispense any volume of any ingredient of any viscosity into any well.

4.9/5.0
|3 Reviews
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TEMPEST® Liquid Dispenser

FORMULATRIX®, Inc.

The TEMPEST ®  is a high throughput, multiple reagent dispensing platform. With up-to 96 independently controllable dispensing nozzles it can be a plate-filling workhorse or a flexible assay-development partner, adapting to your needs on the fly. Used in a broad range of application areas such as cell-based and biochemical assays; molecular biology and NGS; as well as high-throughput screening.

4.7/5.0
|8 Reviews
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Genizer Online Liposome Extruder

Genizer

The Genizer Online Extruder works with a high-pressure homogenizer to reduce the number of passes needed for optimal liposome size distribution and desired particle sizes. The homogenizer's diamond interaction chamber pre-treats the liposome sample to the nanoscale.

5.0/5.0
|1 Review
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NucleoCounter® NC-200™ automated cell counter

ChemoMetec

The NucleoCounter® NC-200™ is a high precision automated cell counter utilizing state-of-the-art image cytometry. With user-adaptable protocols and specialized assays for counting a wide range of mammalian cells, including adipose-derived stem cells, T cells, aggregated cells and cells on microcarriers, the NucleoCounter® NC-200™ provides an all-in-one solution for cell counting and cell viability determinations.

4.8/5.0
|59 Reviews
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Via2-Cassette™ cell counting device

ChemoMetec

The Via2-Cassette™ is our unique cell sampling device, eliminating human error by combining cell sampling, staining and loading into a single press on a piston. Individually volume-calibrated, it guarantees the highest precision in cell counting. The Via2-Cassette™ is a disposable plastic unit containing the fluorescent dyes used for analysis to ensure user safety and operational ease.

5.0/5.0
|2 Reviews
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NucleoCounter® NC-3000™ advanced cell analyzer

ChemoMetec

The NucleoCounter® NC-3000™ is an advanced image cytometer utilizing fluorescence imaging to characterize cell properties. The NC-3000™ can perform high-speed cell count and viability analyses and it includes plug-and-play analytical assays of mammalian, yeast and insect cells. Pre-defined assays include a unique 5-minute cell cycle assay, a selection of apoptosis assays and a GFP transfection efficiency assay.

4.7/5.0
|6 Reviews
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