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Maestro ZHT

Axion BioSystemsMAESTRO384ZHTAvailable: Worldwide

High-throughput live-cell analysis system

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Easy to use, reproducible and reliable!


Average Rating 5.0

Application Area:

Analyze cell attachment and proliferation.

With the ZHT impedence system we were able to get real time cell attachment and proliferation data of ES and iPS cell. This equipment allowed us to optimize our culturing protocols with confidence.

Review Date: 10 Feb 2022 | Axion BioSystems

Axion BioSystems’ Maestro ZHT™ platform measures cell proliferation, death, morphology, attachment, and signaling label-free and in real-time. Screen drug and biological candidates in 384- and 96-well plate formats. Track immune cell-mediated killing, viral infectivity, cancer cell invasiveness, endothelial barrier function, wound healing, and more.

These high-throughput assays are real-time, continuous, and label-free, revealing the full cellular response profile and kinetics using electrical impedance. Get more complete data without the time- and cost-intensive process of repeating multiple endpoint assays.


Taking care of the assay so you can focus on the science:

  • High-throughput, continuous monitoring of your cells — Up to 384 simultaneous live recordings from your cells. The Maestro ZHT system performs noninvasive electrical measurements from the cultured cell population, circumventing the use of dyes/reporters that can perturb your cells and confound results. Track activity over hours, days, and weeks from the same population of cells label-free and in real-time.
  • Precisely control the cell environment — There is no need for an additional cell culture incubator, saving valuable lab space and money. Maestro Z’s smart environmental chamber finely controls temperature and CO₂ while rejecting electrical noise and mechanical vibrations.
  • Start your assay with the push of a button — “One button setup” means temperature and CO₂ levels automatically adjust on plate docking. Plate usage is logged via an integrated plate barcode scanner for convenient experiment tracking.
  • Review your results faster — The Impedance module with AxIS Z software provides a simplified approach to the setup, execution, and analysis of experiments.
  • See your cells — Sometimes you just want to look at your cells under a microscope. Maestro’s CytoView patented transparent circuit technology allows cell visualization and assay multiplexing.
  • Achieve 21 CFR Part 11 compliance in GLP/GMP labs — Designed with clinical translation and a regulatory environment in mind, the optional GxP Impedance Module makes the assay easy to validate and fully auditable while maintaining many of the streamlined and user-friendly features of AxIS Z.
  • Validate your assay for high-throughput screening — A 384-well cytotoxicity assay using the Maestro ZHT was validated for high-throughput screening, achieving high Z' (Z'=0.81, n=2) with no edge effects.
  • Monitor your experiments from outside the lab — The Maestro Z App allows you to check in on your cells and experiment to ensure everything is running smoothly while you are away from the lab.
  • Increase throughput with multiple Maestros — Simultaneously monitor multiple plates automatically with multiple Maestro support. Save space in your lab by controlling multiple Maestro systems using a single computer.

Multiplex your assay: Maestro + Omni

  • Platform cross-compatibility lets you view live-cell imaging alongside real-time, functional data to enhance your analysis.
  • Monitor electrode coverage and cell morphology to ensure consistent, quality results.
  • Experience no-hassle tracking—the Axion Portal automatically links data via barcode.

Impedance-based assays include but are not limited to:

  • Cytotoxicity and cell viability
  • In vitro potency assay for cancer immunotherapy
  • Barrier function/TEER
  • Cell proliferation, migration, and invasion
  • Anti-viral drugs and viral titer studies
  • GPCR signaling and more


The Maestro ZHT system is available with two software modules: Impedance and GxP Impedance. Select the software modules to match your assay needs:

  • Impedance – Track cell proliferation, morphology, and viability label-free and in real-time. Ideal for immuno-oncology, cytotoxicity, virology, cell migration, cell proliferation, GPCR assays, and many more.
  • GxP Impedance – Achieve FDA 21 CFR Part 11 compliance in GMP/GLP labs with this version of the Impedance Software Module.


  • The Maestro ZHT system is compatible with both 384- and 96-well impedance assay plates.
  • CytoView-Z™ – The Maestro impedance plate with a transparent well bottom for cell visualization and assay multiplexing. Available in 384-well and 96-well plate formats.

Cross-compatible Platforms

The Maestro ZHT system has cross-compatibility with:

  • Omni™ – Compliment your impedance assays with whole-plate images of your cultures. View electrode coverage and culture health over time with just a few clicks in AxIS Z. Compatible with the Omni and Omni Pro 12™ systems.

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