Drug discovery > Basic Research Products & Reviews

R&D GM-CSF -Recombinant Mouse Protein GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF is produced by a number of different cell types in response to cytokine or inflammatory stimuli. Specifications and Use for R&D GM-CSF Source of R&D GM-CSF • A DNA…

The IsoPrime is a high performance gas source stable isotope ratio mass spectrometer designed to operate in dual inlet or continuous flow modes of operation. The modules are designed to handle samples such as solids, liquids or gases and prepare them to be introduced into the ion source of the IRMS as purified gases. Resultant prepared gases such as (H2, CO2, CO, N2, SO2 or N2O) are then ionised and analysed for their isotopic…

The CellTiter 96® AQueous One Solution Cell Proliferation Assay is a colorimetric method for determining the number of viable cells in proliferation, cytotoxicity or chemosensitivity assays. The CellTiter 96® AQueous One Solution Reagent contains a tetrazolium compound [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt; MTS(a)] and an electron coupling reagent (phenazine ethos…

KOD Hot Start DNA Polymerase is a premixed complex of KOD DNA Polymerase and two monoclonal antibodies that inhibit the DNA polymerase and 3´→ 5´ exonuclease activities at ambient temperatures. KOD Hot Start combines the high fidelity, fast extension speed, and outstanding processivity of KOD with the high specificity of an antibody-mediated hot start. Non-specific amplification is reduced because mispriming events that can oc…

Provides high sensitivity over a broad detection range at an economical price.

•Amplified DNA can be analyzed with up to 100 different SSO probes simultaneously •Detection of antibodies in serum directed against up to 100 different antigens in a single well with the sensitivity of flow cytometry •Multiplex reactions reduce labor, consumables and assay time •XY platform allows walk-away analysis from 1 to 96 samples at a time •Convenience of automated analysis

We set a new standard in capillary electrophoresis with the 8-capillary 3500 and 24-capillary 3500xL Genetic Analyzers. The 3500 8-capillary platform can run a wide variety of applications —including de novo sequencing and resequencing (mutational profiling)—as well as microsatellite analysis, MLPA™, LOH, MLST, AFLP® and SNP validation or screening. The majority of applications can be run on a single polymer and capillary arra…

The NimbleGen MS 200 Microarray Scanner is the first scanner optimized to unleash the full potential and capture the complete picture from NimbleGen DNA microarrays. The MS 200 offers 2 micron resolution and heightened sensitivity to achieve high data quality and confident results from high-density NimbleGen microarrays of today and tomorrow. Critical to the the workflow, NimbleScan and SignalMap software are included to ana…

Hitachi's U-3900 Double-Beam Single-Monochromator System and the U-3900H Double-Beam Double-Monochromator System are high-performance, comprehensive, research-grade solutions for a variety of resolution concave diffraction grating. Features and Specifications • Band pass width selectable in discrete steps of 0.1, 0.5, 1, 2, 4, and 5 nm • Stray light < 0.015 %T, NaI 220nm, NaNO2 340nm • Wavelength accuracy of ± 0.1 nm and repro…

Electrify your crimping and decapping operations with the new innovative Wheaton Crimpenstein™. The innovative Crimpenstein™ is engineered to improve productivity and efficiency where vials are capped with aluminum seals. The AC powered Crimpenstein™ crimper/decapper provides fast, consistent results with a simple push of a button. The ability to change jaw-sets offers an unmatched level of flexibility and economy for appli…

The Attune™ Acoustic Focusing Cytometer gives you both high sensitivity and high throughput. With this technology you can control your sample concentration, the flow rate, the number of photons you detect, the length of your experiment, the number of samples you run, and more. And you can get the most out of your cells with dependable results. What’s more, the Attune™ instrument makes all of this easy to do. Key features:…

Solaris qPCR Master Mix has been developed in conjunction with Solaris qPCR Gene Expression Assays for quantification of DNA and cDNA. Optimal qPCR results using probe detection chemistries can be achieved by using this same system of qPCR products. Optimized Solaris qPCR Master Mixes have been developed to ensure the best possible Solaris assay performance. In addition to enhanced performance, these optimized reagents offer…

The Newton CCD camera is ideally suited to high-performance spectroscopic applications. The high-resolution sensors deliver up to 95% QE. Combined with Andor Technology’s low noise electronics, it provides convenient multi-Megahertz readout and USB connectivity. The camera utilizes a 1024 x 255 array of 26μm² pixels with thermoelectric cooling down to -100°C resulting in negligible dark current. The system offers the best perf…

Andor's Compact and Reliable Spectroscopy CCD Technology markets evolve and we all expect to get more for our money. The Andor iDus leads the way, delivering performance that was once the preserve of high-end spectroscopy. The iDus was designed with the lowest noise to provide an ultra sensitive and high dynamic range detector for use in a wide range of both conventional and demanding spectroscopic applications such as fluores…

From the manufacturer’s of the World's most compact and reliable spectroscopic CCD detector, comes a new Near Infrared detector solution, the Andor iDus InGaAs detector array system. With all the benefits you’ve come to expect from the iDus range of detectors, the iDus InGaAs detector offers a choice of 512 or 1024 element linear photodiode arrays (PDA) ideal for NIR spectroscopy with high sensitivity output and high resolutio…

Andor's flagship live cell imaging software, designed with flexibility and power in mind. iQ - image and quantify - occupies a central role in their Revolution product range and provides optimized control of Andor's award winning iXon EMCCD cameras and automation hardware for a range of Bioimaging applications. iQ integrates a range of additional hardware for multi-parameter and multi-modal imaging, including devices such as…

The most reproducible and accurate method of determining the amount of filamentous actin (F-actin) content versus free globular-actin (G-actin) content in a cell population is to use Western blot quantitation of F-actin and G-actin cellular fractions. The general approach is to homogenize cells in F-actin stabilization buffer, followed by centrifugation to separate the F-actin from G-actin pool. The fractions are then separate…

These bacterial expression vectors carry the gene for either GFP (wild type Aequorea victoria green fluorescent protein) or GFPuv (a GFP variant optimized for maximal fluorescence when excited by UV light [360–400 nm]) and are driven by the lac promoter. These vectors can also be used as a source of the indicated fluorescent protein coding sequences. The fluorescent protein gene can be amplified by PCR or readily excised using…

Lipofectamine™ RNAiMAX Transfection Reagent from Invitrogen   Invitrogen Lipofectamine™ RNAiMAX Transfection Reagent is a proprietary RNAi-specific cationic lipid formulation that offers the highest transfection efficiencies on the widest variety of cell types for siRNA gene knockdown experiments. With Invitrogen Lipofectamine™ RNAiMAX Transfection Reagent you will get: • Superior transfection efficiency requiring…

The pGEM®-T Easy Vector Systems are convienent systems to clone PCR products.   They offer all of the advantages of the pGEM®-T Vector Systems with added convieneice of recognition sites for EcoRI and NotI flankin the insertion site. Thus, several options exist to remove the desired insert DNA with a single restriction digestion. The pGEM(R)-T Easy Vectr System II contains JM109 Competent Cells in addition to all pf the…

iVision‐Mac is image acquisition, processing, measurement, and analysis software. iVision‐Mac directly supports the acquisition of images and time-lapse series. Sophisticated imaging processes or even simple routines can be automated down to the push of a single button through the use of the intuitive scripting tool. There is no need to learn Visual Basic or other programming languages when you want to automate your imaging ro…

Automated high-throughput tissue homogenizer and cell lyser

The Crystal Phoenix is the ideal protein crystallography dispenser, featuring accuracy, speed and precision to make it the perfect instrument for sitting drop, hanging drop and microbatch reactions. In less than 50 seconds it dispenses protein and screen to the small wells or hanging drop seals. The speed of dispensing the screen and protein eliminates the problem of evaporation even when dispensing as little as 100 nanolite…