GlycoWorks HILIC uElution Plate
The GlycoWorks Product Line was developed and designed to compliment the existing Waters Glycan Application Solution. Concentrating on 2-AB labeled N-Glycan, this sample preparation offering and complimentary standards provides a unique, comprehensive yet versatile solution. The GlycoWorks HILIC uElution Plate is ideal for removing contaminants like salts and detergents from hydrophilic analytes, such as carbohydrates, prior…
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Excellent productc
Biopharmaceuticals
The plates are very user friendly and so far work really well. Never had an issue with this product
Review Date: 26 Mar 2019 | Waters
The GlycoWorks Product Line was developed and designed to compliment the existing Waters Glycan Application Solution. Concentrating on 2-AB labeled N-Glycan, this sample preparation offering and complimentary standards provides a unique, comprehensive yet versatile solution.
The GlycoWorks HILIC uElution Plate is ideal for removing contaminants like salts and detergents from hydrophilic analytes, such as carbohydrates, prior to mass spectrometry analysis.
It enables elution volumes as low as 25 µL, thereby eliminating time-consuming evaporation steps. The eluted carbohydrates can be analyzed directly by MALDI MS without any prior derivatization.
This plate can be used alone for the purpose of extracting carbohydrates, or it can be used as part of our glycan analysis kit (Waters MassPREP Glycoanalysis Kit) to clean up the glycans released from glycoproteins after deglycosylation.
Biopharmaceutical Solutions: A New Way to Look at Biomolecules
Download this application note to see how Waters provides solutions to current biopharmaceutical issues. By 2014, five of the top five - and 50% of the top 100 - best-selling branded drugs will be proteins. Is your organization positioned to be one of the biopharmaceutical leaders?
Rapid Preparation of Released <i>N</i>-Glycans for HILIC Analysis Using a Novel Fluorescence and MS-Active Labeling Reagent
Conventional approaches to the preparation of N-glycans for HILIC-FLR-MS are either laborious, time-consuming, or require compromises in sensitivity. This application note describes a the development of the GlycoWorks RapiFluorFluor-MS N-Glycan Kit, designed to address the shortcomings described above by enabling unprecedented sensitivity for glycan detection while also improving the throughput of N-glycan sample preparation.
GlycoWorks HILIC SPE Robust Glycan Sample Preparation
This application note demonstrates how GlycoWorks HILIC SPE offers a robust, reliable solution for cleanup and concentration of glycans from complex matrices. Its application during the sample preparation of 2-AB labeled glycans helps ensure that an analyst reliably obtains successful results when studying protein glycosylation.
Optimization of GlycoWorks HILIC SPE for the Quantitative and Robust Recovery of N-Linked Glycans from mAb-Type Samples
This application note evaluates HILIC SPE sample preparation to ensure quantitative recovery of both unlabeled and labeled N-glycans. A test mixture, including a complex array of 2-AB labeled human IgG glycans spiked with both high mannose and trisialylated glycans, was used to interrogate and optimize SPE recoveries as well as study the robustness of optimized elution conditions.
