Xevo TQD Triple Quadrupole mass Spectrometer

Food fraud can result in major food safety issues. Interestingly, honey is frequently subjected to fradulent mislabelling and adulteration due to it's high value as a food commodity. Traditional methods of characterization involves complex pollen analyses, which can produce erroneous and non-specific results. This application note describes the verification of honeys from different botanical origins using UPLC-MS/MS.

Explore the analytical capabilities of Waters LC-MS/MS technology for analytes commonly used in the areas of endocrinology and therapeutic drug monitoring (TDM) work in the clinical laboratory.

The bioavailability of busulfan varies greatly between individuals due to factors such as age, underlying diseases and drug-drug interactions. In this application note, an analytically sensitive and selective clinical research method has been developed for the analysis of plasma busulfan.

This white paper reviews various experimental parameters that influence the chromatographic performance of a trap-and-elute nanoLC method. The most important step in the method development process is to select an appropriate column and trap pair that maximizes chromatographic resolution so that the method is capable of thoroughly identifying proteolytic peptides.

Several challenges exist with quantification analysis of cocaine in post mortem samples in the field of forensic toxicology. Rapid half-life due to hydrolysis within hours of death is just one of these. While difficult to quantify in blood, urine and soft tissues, alternative matrices such as hair and bone can be useful in detecting chronic drug use in post-mortem toxicology cases. A robust extraction and cleanup method is required to efficiently extract drugs from complex matrices like bone, reach a target limit of detection and maintain instrument performance. The use of UPLC-MS/MS has allowed analysts to detect trace levels of analytes by following this method.

Join us at the 64th ASMS Conference on Mass Spectrometry and Allied Topics and find out more about Waters latest technologies and innovations that enable superior performance in your lab, allowing you to succeed in the science of what’s possible.

Starting on Saturday, June 4th, be sure to attend Waters MS Users’ Meeting at ASMS 2016 at the San Antonio Marriott Rivercenter, where you'll hear from renowned guest speakers, who are leading the way in the field of mass spectrometry and join other MS users at the afternoon parallel sessions covering key application areas.
Join us for breakfast June 6th, 7th and 8th at one of 7 informative technical seminars.

Get a sneak preview now of the many new mass spectrometry products and technologies we'll be showing you in our Waters Hospitality Suite in Texas Ballrooms B & C at the Grand Hyatt San Antonio.

Don't forget to review the various oral and poster presentations Waters experts will be giving and download the presentation schedule so you can add to your daily agenda.

See you at ASMS in San Antonio!

This poster evaluates an LC-MS/MS method used to measure serum testosterone and androstenedione enabling investigation of metabolic dysfunction for clinical research purposes. Testosterone, and its precursor, androstenedione, are androgenic steroid hormones that play a central role in the regulation of sexual characteristics.

The use of spot testing is the most known technique in forensic analysis for rapid results. For a complete legal identification, a more robust methodology is required, often LC-MS or LC-MS/MS. However, to achieve satisfactory results most often with trace level detection requirements, extensive and time consuming sample preparation protocols and required to reach sub ppb levels. This application note demonstrates the use of multi-dimensional chromatography as a micro extraction technique and sequential 2D extraction for the analysis.

In this application note, we report a highly sensitive and efficient LC-MS/MS method for simultaneously analyzing MG, LMG, CV, LCV, and BG using the Waters® ACQUITY UPLC H-Class System with the Xevo TQD.

The use of pesticides in various stages of cultivation of basmati rice has increased in order to improve its production yield. A multi-residue pesticide method has been developed for the determination of pesticides in basmati rice. This application note shows the analysis of over 200 pesticides using a simple QuEChERS sample preparation procedure, followed by UltraPerformance LC® (UPLC®) couple to tandem quadrupole mass spectrometry.

Mass spectrometers from Waters Corporation are used for reliable detection of analytes in urine, blood and CSF, offering an attractive alternative to immunoassays. Watch this video to find out more.

As a leading clinical LC-MS/MS solutions partner, Waters is a trusted provider of in vitro diagnostic medical devices, consumables, informatics, and support services for high performance LC-MS/MS systems. Learn how and why University Hospital of South Manchester has introduced Waters LC-MS/MS IVD instrumentation into their busy clinical laboratory.

Watch this video to find out about some of the clinical LC/MS devices available from Waters. Learn more about how this technology allows clinical laboratories to address an unmet need in areas from toxicology and therapeutic drug testing to endocrinology.

Technology brings University scientists unparalleled potential for chemical, biological and human disease research

Prepare for the American Society for Mass Spectrometry(ASMS) Annual Meeting by discovering the many applications of mass spectrometry – from pesticide detection to imaging for cancer therapy