Xevo TQ MS

Boronic acids and their esters are common reagents used in the synthesis of organic compounds. Several boronic acids have been identified as potential mutagens and should be controlled at low levels using sensitive methods. In this application note, Waters describes an Ultra Performance Liquid Chromatography (UPLC) method with tandem quadrupole mass spectrometer for high sensitivity quantification of seven boronic acids with mutagenic potential.

In this application note, Waters demonstrates how the app-based compliance-ready waters_connect™ informatics platform can be used with the Xevo™ G3 QTof for biosimilar mAb characterization and monitoring.

In this application note, Waters demonstrates the use of Xevo™ G3 QTof platform to perform a comparability analysis for infliximab innovator Remicade® and three biosimilars (Inflectra®, Avsola®, and Renflexis®).

The ability to analyze peptides and proteins is becoming increasingly important in the field of biotheraputics. This infographic explains why quantifying large molecules is challenging and how Waters can provide solutions.

This application note describes a sensitive LC-MS/MS quantification method for the robust analysis of highly polar pesticides in food commodities without the need of derivatization. Using the ACQUITY UPLC System coupled to the Xevo TQ-XS Triple Quadrupole Mass Spectrometer, they achieved sub-parts per billion detection (ppb) limits for glyphosate, glufosinate and aminomethylphosphonic acid (AMPA). The sensitivity of the Xevo TQ-XS promises excellent limits of detection, suitable for monitoring maximum residue limit (MRL) compliance for these challenging analytes and good quantitative performance, in terms of precision and calibration characteristics in compliance with SANTE 11954/2015 guidelines.

This application note presents QuEChERS extraction and SPE-based cleanup strategies for multi-residue pesticide analysis of dried teas. The tea sample is first equilibrated with water before extraction using the DisQuE pouch for CEN QuEChERS. Then, three aliquots are taken for further analysis.

In this white paper, the benefits and analytical considerations for MS analysis of polymers is considered. The benefit of mass spectrometry is the ability to make absolute mass measurements at a molecular level rather than an average across a whole sample, making mixtures easier to deal with. Dual-stage mass spectrometry (MS/MS) can provide detailed structural information about the repeat unit chemistry, end groups and backbone connectivity with both detail and confidence.

This application note describes the use of the Ostro Plate for multi-residue screening for veterinary drugs in milk. Using this plate, milk samples are prepared using a few simple steps to effectively precipitate protein and remove potential interferences.

Measurement of 17-hydroxyprogesterone (17-OHP) by immunoassay is prone to analytical interference arising from cross-reactivity of reagent antibodies with structurally-related steroid metabolites. In this application note, a method for the extraction and UPLC®-MS/MS analysis of serum 17-OHP and two additional adrenal steroids, androstenedione (A4) and cortisol, using the ACQUITY UPLC System with the Xevo TQ MS is described.

To maintain high quality reproducible data, RADAR™ was introduced on the Xevo® TQ MS instruments. This white paper describes how RADAR mode makes it possible to monitor matrix interferences, metabolites, impurities and degradants in a sample while accurately quantifying target compounds without losing sensitivity or performance. Understanding the matrix of individual samples and monitoring changes in matrix across different samples will lead to continuous improvement of quality of the services provided by the laboratory.

Watch this video to find out more about metabolic profiling and its use in analyzing athletic performance at the Rio Olympic Games in 2016.

Discover how the mass spectrometry analysis is used to help Bruno manage his hydration and glucose levels, to ensure he performs at the optimum level and recovers properly.

Watch this video to find out about the independent testing of dietary supplements by Analytical Laboratories to ensure that these meet FDA regulations. Analytical Laboratories analyzes complex, multi-ingredient samples and scans up to 300 pesticides in 1 run, using Waters ACQUITY UPLC systems coupled to Xevo MS. This enables fast analysis with high resolution whilst providing savings on reagents compared to traditional HPLC.

In this video, find out about the work of Didier Ortelli and the Service for Consumers and Veterinary Affairs (SCAV) in Geneva. They are responsible for ensuring food safety and environmental testing. Recent tests included taking water samples from Lake Geneva and analyzing for contaminants; a very high concentration of Sulfuron was found that would normally correlate with 150 years of agricultural usage.

Read this exclusive interview with Louise Kenny, one of the founding directors of the INFANT Centre, to discover how they are using mass spectrometry to research preeclampsia and pre-term birth

Laboratory applies analytical chemistry to solve drug-related crimes

Hear what the UNIRIO professor has to say