Thermo Scientific™ Acclaim™ Trinity P2 LC Column
The Thermo Scientific™ Acclaim™ Trinity™ P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC). This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one co…
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The Thermo Scientific™ Acclaim™ Trinity™ P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC).
This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one column and one method on a standard HPLC instrument.
The Acclaim Trinity P2 column is based on nanopolymer silica hybrid (NSH) technology. It consists of high-purity, porous, 3 µm particles coated with charged nanopolymer particles: the innerpore area of the silica particles is modified with a covalently bonded hydrophilic layer that provides cation exchange retention, while the outer surface is modified with anion-exchange nanopolymer beads. This chemistry design ensures spatial separation of the anion exchange and cation exchange regions. In addition, its hydrophilic surface makes it useful as a hydrophilic interaction liquid chromatography (HILIC) column. Thus, the Acclaim Trinity P2 column provides cation-exchange, anion-exchange, and HILIC retentions on the same stationary phase.
Acclaim Trinity P2 LC Column Features:
- Desired selectivity for pharmaceutical mono- and multi-valent counterion screening
- Retention of ionic and ionizable analytes without using ion-pairing reagents
- Compatibility with charged aerosol and mass spectrometry detection methods
- Easy to use
- Rugged packing
Column Characteristics:
- Chemistry: SAX, WCX and HILIC Mixed-Mode
- Particle Size: 3 µm
- Length: 50, 100 mm
- ID: 3.0 mm
Analysis of a Sports Beverage for Electrolytes and Sugars Using Multi-Mode Chromatography with Charged Aerosol Detection
The analysis of sports beverages provides an interesting analytical challenge in that the carbohydrates, anions, and cations are all functional ingredients that require determination. This application note describes the analysis of a sports beverage for electrolytes and sugars using the Thermo Scientific™ Acclaim™ Trinity™ P2 column and Thermo Scientific™ Dionex™ Corona™ Veo™ charged aerosol detector (CAD).
Simultaneous Determination of Metformin and its Chloride Counterion Using Multi-Mode Liquid Chromatography with Charged Aerosol Detection
This work demonstrates the determination of metformin (API) and its counterion (chloride) using a simple isocratic method. Thermo Scientific™ Acclaim™ Trinity™ P2 columns offer cation-exchange, anion-exchange and HILIC retention mechanisms on the same phase, thus they are ideal for separating both cationic and anionic species simultaneously.
Separation of Calcium, Magnesium and Counterions in a Dietary Supplement Using Multi-mode Liquid Chromatography with Charged Aerosol Detection
This application note describes the simultaneous determination of calcium, magnesium and their counterion (citrate) in a dietary supplement under gradient elution conditions using a Thermo Scientific™ Acclaim™ Trinity™ P2 column and Thermo Scientific™ Dionex™ Corona™ Veo™ Charged Aerosol Detector (CAD).
API and Counterions in Adderall® Using Multi-Mode Liquid Chromatography with Charged Aerosol Detection
This application note demonstrates the determination of the API (amphetamine) and counterions (aspartate, saccharin and sulfate) in a medicine Adderall® within a single analysis using a Thermo Scientific™ Acclaim™ Trinity™ P2 column and Thermo Scientific™ Dionex™ Corona™ Veo™ Charged Aerosol Detector (CAD).
