RapidFire 400 by Agilent Technologies

Manufacturer Agilent Technologies  |  Available Worldwide
High Throughput LC/MS

RapidFire 400 by Agilent Technologies product image
RapidFire 400
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The Agilent RapidFire 400 is an integrated autosampler for ultrafast sample cleanup based on automated solid phase extraction (SPE) and introduction to mass spectrometry. Designed for highest-throughput laboratories, the large capacity, temperature-controlled, 1536 well-plate handling robot allows unattended weekend operation with sample injection times as short as 8 seconds. RapidFire 400 builds on successful previous models, combining more than 14 years of high-throughput mass spectrometry innovation.

This system provides reliable high throughput and accurate measurements for the qualification of drug targets like automated ADME in discovery, compound binding assessment, elucidation of metabolic processes, the discovery of novel metabolomics targets, and much more. Fully controlled by a single PC, the RapidFire 400 can be combined with any Agilent LC/Q-TOF or LC/TQ, while integrating the Ultivo LC/TQ into the system dramatically reduces the footprint of the autosampler and mass spec combination.


  • Robot can be used with Agilent triple quadrupole, time-of-flight, and quadrupole time-of-flight mass spectrometers, using a single control software
  • Integrating the Ultivo LC/TQ into the RapidFire 400 footprint saves valuable lab space
  • Enables different assays in a single batch based on innovative fluidics using proven Agilent 1260 Infinity II quaternary pumps
  • Ultrafast data acquisition reduces data acquisition from minutes to seconds by eliminating chromatography
  • Large sample capacity allows longer unattended runs with storage for over 98,000 samples in 1536-well plates
  • Temperature-controlled sample storage unit stores samples longer without compromising integrity
  • Integrated plate handler robot simplifies batch configuration
  • Barcode reading ensures sample integrity and tracking from loading to analysis
  • With less than 0.5 mL of solvent per sample required and SPE cartridges reusable for thousands of samples, solvent use and waste generation are substantially reduced